TY - GEN
T1 - Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin
AU - Saravanakumar, Gurusamy
AU - Shin, Jung Min
AU - Park, Jae Hyung
PY - 2013
Y1 - 2013
N2 - Reduction-sensitive, amphiphilic HA conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction, and evaluated their potential as the carrier for intracellular delivery of the hydrophobic anticancer drug, doxorubicin (DOX). The HA-SS-DDT conjugates formed self-assembled nanoparticles in aqueous conditions, and DOX was successfully encapsulated into the nanoparticles by an oil-in-water emulsion method. The release rate of DOX from the DOX-loaded HA-SS-DDT (HA-SS-DDT-DOX) nanoparticles was accelerated in the presence of 10 mM glutathione, mimicking the intracellular condition. The HA-SS-DDT-DOX nanoparticles were efficiently taken up by SCC7 cancer cells that over-express the HA receptor (CD44). These results suggest that the HA-SS-DDT nanoparticles have the promising potential as the carrier of DOX for cancer therapy.
AB - Reduction-sensitive, amphiphilic HA conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction, and evaluated their potential as the carrier for intracellular delivery of the hydrophobic anticancer drug, doxorubicin (DOX). The HA-SS-DDT conjugates formed self-assembled nanoparticles in aqueous conditions, and DOX was successfully encapsulated into the nanoparticles by an oil-in-water emulsion method. The release rate of DOX from the DOX-loaded HA-SS-DDT (HA-SS-DDT-DOX) nanoparticles was accelerated in the presence of 10 mM glutathione, mimicking the intracellular condition. The HA-SS-DDT-DOX nanoparticles were efficiently taken up by SCC7 cancer cells that over-express the HA receptor (CD44). These results suggest that the HA-SS-DDT nanoparticles have the promising potential as the carrier of DOX for cancer therapy.
KW - Doxorubicin
KW - Drug delivery
KW - Hyaluronic acid nanoparticle
KW - Reduction-sensitive
UR - https://www.scopus.com/pages/publications/84881103705
M3 - Conference contribution
AN - SCOPUS:84881103705
SN - 9781482205862
T3 - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
SP - 289
EP - 292
BT - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
T2 - Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Y2 - 12 May 2013 through 16 May 2013
ER -
