Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin

Gurusamy Saravanakumar; Jung Min Shin; Jae Hyung Park

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin

Gurusamy Saravanakumar
, Jung Min Shin
, Jae Hyung Park

Department of Chemical Engineering

Sungkyunkwan University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Reduction-sensitive, amphiphilic HA conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction, and evaluated their potential as the carrier for intracellular delivery of the hydrophobic anticancer drug, doxorubicin (DOX). The HA-SS-DDT conjugates formed self-assembled nanoparticles in aqueous conditions, and DOX was successfully encapsulated into the nanoparticles by an oil-in-water emulsion method. The release rate of DOX from the DOX-loaded HA-SS-DDT (HA-SS-DDT-DOX) nanoparticles was accelerated in the presence of 10 mM glutathione, mimicking the intracellular condition. The HA-SS-DDT-DOX nanoparticles were efficiently taken up by SCC7 cancer cells that over-express the HA receptor (CD44). These results suggest that the HA-SS-DDT nanoparticles have the promising potential as the carrier of DOX for cancer therapy.

Original language	English
Title of host publication	Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages	289-292
Number of pages	4
State	Published - 2013
Event	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States Duration: 12 May 2013 → 16 May 2013

Publication series

Name	Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Volume	3

Conference

Conference	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Country/Territory	United States
City	Washington, DC
Period	12/05/13 → 16/05/13

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Doxorubicin
Drug delivery
Hyaluronic acid nanoparticle
Reduction-sensitive

Cite this

Saravanakumar, G., Shin, J. M., & Park, J. H. (2013). Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (pp. 289-292). (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013; Vol. 3).

Saravanakumar, Gurusamy ; Shin, Jung Min ; Park, Jae Hyung. / Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin. Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. 2013. pp. 289-292 (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013).

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title = "Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin",

abstract = "Reduction-sensitive, amphiphilic HA conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction, and evaluated their potential as the carrier for intracellular delivery of the hydrophobic anticancer drug, doxorubicin (DOX). The HA-SS-DDT conjugates formed self-assembled nanoparticles in aqueous conditions, and DOX was successfully encapsulated into the nanoparticles by an oil-in-water emulsion method. The release rate of DOX from the DOX-loaded HA-SS-DDT (HA-SS-DDT-DOX) nanoparticles was accelerated in the presence of 10 mM glutathione, mimicking the intracellular condition. The HA-SS-DDT-DOX nanoparticles were efficiently taken up by SCC7 cancer cells that over-express the HA receptor (CD44). These results suggest that the HA-SS-DDT nanoparticles have the promising potential as the carrier of DOX for cancer therapy.",

keywords = "Doxorubicin, Drug delivery, Hyaluronic acid nanoparticle, Reduction-sensitive",

author = "Gurusamy Saravanakumar and Shin, \{Jung Min\} and Park, \{Jae Hyung\}",

year = "2013",

language = "English",

isbn = "9781482205862",

series = "Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013",

pages = "289--292",

booktitle = "Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013",

note = "Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 ; Conference date: 12-05-2013 Through 16-05-2013",

}

Saravanakumar, G, Shin, JM & Park, JH 2013, Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin. in Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013, vol. 3, pp. 289-292, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013, Washington, DC, United States, 12/05/13.

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin. / Saravanakumar, Gurusamy; Shin, Jung Min; Park, Jae Hyung.
Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. 2013. p. 289-292 (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013; Vol. 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin

AU - Saravanakumar, Gurusamy

AU - Shin, Jung Min

AU - Park, Jae Hyung

PY - 2013

Y1 - 2013

N2 - Reduction-sensitive, amphiphilic HA conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction, and evaluated their potential as the carrier for intracellular delivery of the hydrophobic anticancer drug, doxorubicin (DOX). The HA-SS-DDT conjugates formed self-assembled nanoparticles in aqueous conditions, and DOX was successfully encapsulated into the nanoparticles by an oil-in-water emulsion method. The release rate of DOX from the DOX-loaded HA-SS-DDT (HA-SS-DDT-DOX) nanoparticles was accelerated in the presence of 10 mM glutathione, mimicking the intracellular condition. The HA-SS-DDT-DOX nanoparticles were efficiently taken up by SCC7 cancer cells that over-express the HA receptor (CD44). These results suggest that the HA-SS-DDT nanoparticles have the promising potential as the carrier of DOX for cancer therapy.

AB - Reduction-sensitive, amphiphilic HA conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction, and evaluated their potential as the carrier for intracellular delivery of the hydrophobic anticancer drug, doxorubicin (DOX). The HA-SS-DDT conjugates formed self-assembled nanoparticles in aqueous conditions, and DOX was successfully encapsulated into the nanoparticles by an oil-in-water emulsion method. The release rate of DOX from the DOX-loaded HA-SS-DDT (HA-SS-DDT-DOX) nanoparticles was accelerated in the presence of 10 mM glutathione, mimicking the intracellular condition. The HA-SS-DDT-DOX nanoparticles were efficiently taken up by SCC7 cancer cells that over-express the HA receptor (CD44). These results suggest that the HA-SS-DDT nanoparticles have the promising potential as the carrier of DOX for cancer therapy.

KW - Doxorubicin

KW - Drug delivery

KW - Hyaluronic acid nanoparticle

KW - Reduction-sensitive

UR - https://www.scopus.com/pages/publications/84881103705

M3 - Conference contribution

AN - SCOPUS:84881103705

SN - 9781482205862

T3 - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

SP - 289

EP - 292

BT - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

T2 - Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

Y2 - 12 May 2013 through 16 May 2013

ER -

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular delivery of doxorubicin

Abstract

Publication series

Conference

UN SDGs

Keywords

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