Recent advances in exosome‐based drug delivery for cancer therapy

Hyosuk Kim; Hochung Jang; Haeun Cho; Jiwon Choi; Kwang Yeon Hwang; Yeonho Choi; Sun Hwa Kim; Yoosoo Yang

doi:10.3390/cancers13174435

Recent advances in exosome‐based drug delivery for cancer therapy

Hyosuk Kim
, Hochung Jang
, Haeun Cho
, Jiwon Choi
, Kwang Yeon Hwang
, Yeonho Choi
, Sun Hwa Kim
, Yoosoo Yang

Korea Institute of Science and Technology
University of Science and Technology UST
Korea University

Research output: Contribution to journal › Review article › peer-review

159 Scopus citations

Abstract

Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocom-patibility and low immunogenicity for efficient delivery of therapeutic agents such as chemothera-peutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of ex-osome‐based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.

Original language	English
Article number	4435
Journal	Cancers
Volume	13
Issue number	17
DOIs	https://doi.org/10.3390/cancers13174435
State	Published - 1 Sep 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer therapy
Drug delivery system
Exosome
Exosome engineering

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10.3390/cancers13174435

Cite this

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title = "Recent advances in exosome‐based drug delivery for cancer therapy",

abstract = "Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocom-patibility and low immunogenicity for efficient delivery of therapeutic agents such as chemothera-peutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of ex-osome‐based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.",

keywords = "Cancer therapy, Drug delivery system, Exosome, Exosome engineering",

author = "Hyosuk Kim and Hochung Jang and Haeun Cho and Jiwon Choi and Hwang, \{Kwang Yeon\} and Yeonho Choi and Kim, \{Sun Hwa\} and Yoosoo Yang",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Li-censee MDPI, Basel, Switzerland.",

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month = sep,

day = "1",

doi = "10.3390/cancers13174435",

language = "English",

volume = "13",

journal = "Cancers",

issn = "2072-6694",

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TY - JOUR

T1 - Recent advances in exosome‐based drug delivery for cancer therapy

AU - Kim, Hyosuk

AU - Jang, Hochung

AU - Cho, Haeun

AU - Choi, Jiwon

AU - Hwang, Kwang Yeon

AU - Choi, Yeonho

AU - Kim, Sun Hwa

AU - Yang, Yoosoo

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocom-patibility and low immunogenicity for efficient delivery of therapeutic agents such as chemothera-peutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of ex-osome‐based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.

AB - Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocom-patibility and low immunogenicity for efficient delivery of therapeutic agents such as chemothera-peutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of ex-osome‐based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.

KW - Cancer therapy

KW - Drug delivery system

KW - Exosome

KW - Exosome engineering

UR - https://www.scopus.com/pages/publications/85114111356

U2 - 10.3390/cancers13174435

DO - 10.3390/cancers13174435

M3 - Review article

AN - SCOPUS:85114111356

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 17

M1 - 4435

ER -

Recent advances in exosome‐based drug delivery for cancer therapy

Abstract

UN SDGs

Keywords

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