Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

Young Tae Chang; Gildon Choi; Yoe Sik Bae; Matthew Burdett; Ho Sang Moon; Jae Wook Lee; Nathanael S. Gray; Peter G. Schultz; Laurent Meijer; Sung Kee Chung; Kwan Yong Choi; Pann Ghill Suh; Sung Ho Ryu

doi:10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

Young Tae Chang
, Gildon Choi
, Yoe Sik Bae
, Matthew Burdett
, Ho Sang Moon
, Jae Wook Lee
, Nathanael S. Gray
, Peter G. Schultz
, Laurent Meijer
, Sung Kee Chung
, Kwan Yong Choi
, Pann Ghill Suh
, Sung Ho Ryu

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC₅₀= 10.2 μm). This new IP3K inhibitor 1 increased Ca²⁺ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.

Original language	English
Pages (from-to)	897-901
Number of pages	5
Journal	ChemBioChem
Volume	3
Issue number	9
DOIs	https://doi.org/10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B
State	Published - 2002
Externally published	Yes

Keywords

Enzymes
Inhibitors
Kinases phosphorylation
Purines

Access to Document

10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

Cite this

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title = "Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase",

abstract = "Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 μm). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.",

keywords = "Enzymes, Inhibitors, Kinases phosphorylation, Purines",

author = "Chang, \{Young Tae\} and Gildon Choi and Bae, \{Yoe Sik\} and Matthew Burdett and Moon, \{Ho Sang\} and \{Wook Lee\}, Jae and Gray, \{Nathanael S.\} and Schultz, \{Peter G.\} and Laurent Meijer and Chung, \{Sung Kee\} and \{Yong Choi\}, Kwan and Suh, \{Pann Ghill\} and Ryu, \{Sung Ho\}",

year = "2002",

doi = "10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B",

language = "English",

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pages = "897--901",

journal = "ChemBioChem",

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publisher = "John Wiley and Sons Inc",

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TY - JOUR

T1 - Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

AU - Chang, Young Tae

AU - Choi, Gildon

AU - Bae, Yoe Sik

AU - Burdett, Matthew

AU - Moon, Ho Sang

AU - Wook Lee, Jae

AU - Gray, Nathanael S.

AU - Schultz, Peter G.

AU - Meijer, Laurent

AU - Chung, Sung Kee

AU - Yong Choi, Kwan

AU - Suh, Pann Ghill

AU - Ryu, Sung Ho

PY - 2002

Y1 - 2002

N2 - Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 μm). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.

AB - Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 μm). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.

KW - Enzymes

KW - Inhibitors

KW - Kinases phosphorylation

KW - Purines

UR - https://www.scopus.com/pages/publications/12244284906

U2 - 10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

DO - 10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

M3 - Article

C2 - 12210991

AN - SCOPUS:12244284906

SN - 1439-4227

VL - 3

SP - 897

EP - 901

JO - ChemBioChem

JF - ChemBioChem

IS - 9

ER -

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

Abstract

Keywords

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