Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

Young Tae Chang; Gildon Choi; Yoe Sik Bae; Matthew Burdett; Ho Sang Moon; Jae Wook Lee; Nathanael S. Gray; Peter G. Schultz; Laurent Meijer; Sung Kee Chung; Kwan Yong Choi; Pann Ghill Suh; Sung Ho Ryu

doi:10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

Young Tae Chang, Gildon Choi, Yoe Sik Bae, Matthew Burdett, Ho Sang Moon, Jae Wook Lee, Nathanael S. Gray, Peter G. Schultz, Laurent Meijer, Sung Kee Chung, Kwan Yong Choi, Pann Ghill Suh, Sung Ho Ryu

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC₅₀= 10.2 μm). This new IP3K inhibitor 1 increased Ca²⁺ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.

Original language	English
Pages (from-to)	897-901
Number of pages	5
Journal	ChemBioChem
Volume	3
Issue number	9
DOIs	https://doi.org/10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B
State	Published - 2002
Externally published	Yes

Keywords

Enzymes
Inhibitors
Kinases phosphorylation
Purines

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10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

Cite this

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title = "Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase",

abstract = "Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 μm). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.",

keywords = "Enzymes, Inhibitors, Kinases phosphorylation, Purines",

author = "Chang, \{Young Tae\} and Gildon Choi and Bae, \{Yoe Sik\} and Matthew Burdett and Moon, \{Ho Sang\} and \{Wook Lee\}, Jae and Gray, \{Nathanael S.\} and Schultz, \{Peter G.\} and Laurent Meijer and Chung, \{Sung Kee\} and \{Yong Choi\}, Kwan and Suh, \{Pann Ghill\} and Ryu, \{Sung Ho\}",

year = "2002",

doi = "10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B",

language = "English",

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pages = "897--901",

journal = "ChemBioChem",

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TY - JOUR

T1 - Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

AU - Chang, Young Tae

AU - Choi, Gildon

AU - Bae, Yoe Sik

AU - Burdett, Matthew

AU - Moon, Ho Sang

AU - Wook Lee, Jae

AU - Gray, Nathanael S.

AU - Schultz, Peter G.

AU - Meijer, Laurent

AU - Chung, Sung Kee

AU - Yong Choi, Kwan

AU - Suh, Pann Ghill

AU - Ryu, Sung Ho

PY - 2002

Y1 - 2002

N2 - Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 μm). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.

AB - Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 μm). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C.

KW - Enzymes

KW - Inhibitors

KW - Kinases phosphorylation

KW - Purines

UR - https://www.scopus.com/pages/publications/12244284906

U2 - 10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

DO - 10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B

M3 - Article

C2 - 12210991

AN - SCOPUS:12244284906

SN - 1439-4227

VL - 3

SP - 897

EP - 901

JO - ChemBioChem

JF - ChemBioChem

IS - 9

ER -

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

Abstract

Keywords

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