Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as type I diabetes models

Phil Young Lee; Sung Goo Park; Eun Young Kim; Myung Sup Lee; Sang J. Chung; Sang Chul Lee; Dae Yeul Yu; Kwang Hee Bae

doi:10.4014/jmb.0909.09027

Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as type I diabetes models

Phil Young Lee
, Sung Goo Park
, Eun Young Kim
, Myung Sup Lee
, Sang J. Chung
, Sang Chul Lee
, Dae Yeul Yu
, Kwang Hee Bae

Korea Research Institute of Bioscience and Biotechnology
Medi Kinetics Co., Ltd

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by extreme insulin deficiency due to an overall reduction in the mass of functional pancreatic β-cells. Several animal models have been used to study T1DM. Amongst these, the mini-pig seems to be the most ideal model for diabetes research, owing to similarities with humans in anatomy and physiology. The purpose of this study was to analyze differentially expressed pancreatic proteins in a streptozotocin (STZ)-induced mini-pig T1DM model. Pancreas proteins from mini-pigs treated with STZ were separated by two-dimensional gel electrophoresis, and 11 protein spots were found to be altered significantly when compared with control mini-pigs. The data in this study utilizing proteomic analysis provide a valuable resource for the further understanding of the T1DM pathomechanism.

Original language	English
Pages (from-to)	817-820
Number of pages	4
Journal	Journal of Microbiology and Biotechnology
Volume	20
Issue number	4
DOIs	https://doi.org/10.4014/jmb.0909.09027
State	Published - Apr 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mini-pig
Proteomics
Streptozotocin
Type 1 diabetes mellitus

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10.4014/jmb.0909.09027

Cite this

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title = "Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as type I diabetes models",

abstract = "Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by extreme insulin deficiency due to an overall reduction in the mass of functional pancreatic β-cells. Several animal models have been used to study T1DM. Amongst these, the mini-pig seems to be the most ideal model for diabetes research, owing to similarities with humans in anatomy and physiology. The purpose of this study was to analyze differentially expressed pancreatic proteins in a streptozotocin (STZ)-induced mini-pig T1DM model. Pancreas proteins from mini-pigs treated with STZ were separated by two-dimensional gel electrophoresis, and 11 protein spots were found to be altered significantly when compared with control mini-pigs. The data in this study utilizing proteomic analysis provide a valuable resource for the further understanding of the T1DM pathomechanism.",

keywords = "Mini-pig, Proteomics, Streptozotocin, Type 1 diabetes mellitus",

author = "Lee, \{Phil Young\} and Park, \{Sung Goo\} and Kim, \{Eun Young\} and Lee, \{Myung Sup\} and Chung, \{Sang J.\} and Lee, \{Sang Chul\} and Yu, \{Dae Yeul\} and Bae, \{Kwang Hee\}",

year = "2010",

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doi = "10.4014/jmb.0909.09027",

language = "English",

volume = "20",

pages = "817--820",

journal = "Journal of Microbiology and Biotechnology",

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T1 - Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as type I diabetes models

AU - Lee, Phil Young

AU - Park, Sung Goo

AU - Kim, Eun Young

AU - Lee, Myung Sup

AU - Chung, Sang J.

AU - Lee, Sang Chul

AU - Yu, Dae Yeul

AU - Bae, Kwang Hee

PY - 2010/4

Y1 - 2010/4

N2 - Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by extreme insulin deficiency due to an overall reduction in the mass of functional pancreatic β-cells. Several animal models have been used to study T1DM. Amongst these, the mini-pig seems to be the most ideal model for diabetes research, owing to similarities with humans in anatomy and physiology. The purpose of this study was to analyze differentially expressed pancreatic proteins in a streptozotocin (STZ)-induced mini-pig T1DM model. Pancreas proteins from mini-pigs treated with STZ were separated by two-dimensional gel electrophoresis, and 11 protein spots were found to be altered significantly when compared with control mini-pigs. The data in this study utilizing proteomic analysis provide a valuable resource for the further understanding of the T1DM pathomechanism.

AB - Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by extreme insulin deficiency due to an overall reduction in the mass of functional pancreatic β-cells. Several animal models have been used to study T1DM. Amongst these, the mini-pig seems to be the most ideal model for diabetes research, owing to similarities with humans in anatomy and physiology. The purpose of this study was to analyze differentially expressed pancreatic proteins in a streptozotocin (STZ)-induced mini-pig T1DM model. Pancreas proteins from mini-pigs treated with STZ were separated by two-dimensional gel electrophoresis, and 11 protein spots were found to be altered significantly when compared with control mini-pigs. The data in this study utilizing proteomic analysis provide a valuable resource for the further understanding of the T1DM pathomechanism.

KW - Mini-pig

KW - Proteomics

KW - Streptozotocin

KW - Type 1 diabetes mellitus

UR - https://www.scopus.com/pages/publications/77954999998

U2 - 10.4014/jmb.0909.09027

DO - 10.4014/jmb.0909.09027

M3 - Article

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IS - 4

ER -

Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as type I diabetes models

Abstract

UN SDGs

Keywords

Access to Document

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