Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities

Chiranjeev Sharma; Youllee Kim; Dohee Ahn; Sang J. Chung

doi:10.1007/s12272-021-01315-9

Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities

Chiranjeev Sharma
, Youllee Kim
, Dohee Ahn
, Sang J. Chung

Department of Pharmacy

Sungkyunkwan University

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Protein tyrosine phosphatases (PTPs) have an emerging paradigm for the development of antidiabetic drugs. Herein, we provide a comprehensive overview of the relevance of PTPs to type 2 diabetes (T2D) and the therapeutic opportunities thereof, while critically evaluating the potential challenges for PTP inhibitors to be next generation antidiabetics. This review briefly discusses the structure and function of PTPs. An account of importance and relevance of PTPs in various human diseases is presented with special attention to diabetes. The PTPs relevant to T2D have been targeted by small molecule inhibitors such as natural products and synthetic compounds as well as antisense nucleic acids. This review will give better understanding of the important concepts helpful in outlining the strategies for the development of new therapeutic agents with promising antidiabetic activities.

Original language	English
Pages (from-to)	310-321
Number of pages	12
Journal	Archives of Pharmacal Research
Volume	44
Issue number	3
DOIs	https://doi.org/10.1007/s12272-021-01315-9
State	Published - Mar 2021

Keywords

Antidiabetic agents
Antisense
Natural product
PTP inhibitor
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12272-021-01315-9

Cite this

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title = "Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities",

abstract = "Protein tyrosine phosphatases (PTPs) have an emerging paradigm for the development of antidiabetic drugs. Herein, we provide a comprehensive overview of the relevance of PTPs to type 2 diabetes (T2D) and the therapeutic opportunities thereof, while critically evaluating the potential challenges for PTP inhibitors to be next generation antidiabetics. This review briefly discusses the structure and function of PTPs. An account of importance and relevance of PTPs in various human diseases is presented with special attention to diabetes. The PTPs relevant to T2D have been targeted by small molecule inhibitors such as natural products and synthetic compounds as well as antisense nucleic acids. This review will give better understanding of the important concepts helpful in outlining the strategies for the development of new therapeutic agents with promising antidiabetic activities.",

keywords = "Antidiabetic agents, Antisense, Natural product, PTP inhibitor, Type 2 diabetes",

author = "Chiranjeev Sharma and Youllee Kim and Dohee Ahn and Chung, \{Sang J.\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Pharmaceutical Society of Korea.",

year = "2021",

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doi = "10.1007/s12272-021-01315-9",

language = "English",

volume = "44",

pages = "310--321",

journal = "Archives of Pharmacal Research",

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publisher = "Pharmaceutical Society of Korea",

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}

TY - JOUR

T1 - Protein tyrosine phosphatases (PTPs) in diabetes

T2 - causes and therapeutic opportunities

AU - Sharma, Chiranjeev

AU - Kim, Youllee

AU - Ahn, Dohee

AU - Chung, Sang J.

PY - 2021/3

Y1 - 2021/3

N2 - Protein tyrosine phosphatases (PTPs) have an emerging paradigm for the development of antidiabetic drugs. Herein, we provide a comprehensive overview of the relevance of PTPs to type 2 diabetes (T2D) and the therapeutic opportunities thereof, while critically evaluating the potential challenges for PTP inhibitors to be next generation antidiabetics. This review briefly discusses the structure and function of PTPs. An account of importance and relevance of PTPs in various human diseases is presented with special attention to diabetes. The PTPs relevant to T2D have been targeted by small molecule inhibitors such as natural products and synthetic compounds as well as antisense nucleic acids. This review will give better understanding of the important concepts helpful in outlining the strategies for the development of new therapeutic agents with promising antidiabetic activities.

AB - Protein tyrosine phosphatases (PTPs) have an emerging paradigm for the development of antidiabetic drugs. Herein, we provide a comprehensive overview of the relevance of PTPs to type 2 diabetes (T2D) and the therapeutic opportunities thereof, while critically evaluating the potential challenges for PTP inhibitors to be next generation antidiabetics. This review briefly discusses the structure and function of PTPs. An account of importance and relevance of PTPs in various human diseases is presented with special attention to diabetes. The PTPs relevant to T2D have been targeted by small molecule inhibitors such as natural products and synthetic compounds as well as antisense nucleic acids. This review will give better understanding of the important concepts helpful in outlining the strategies for the development of new therapeutic agents with promising antidiabetic activities.

KW - Antidiabetic agents

KW - Antisense

KW - Natural product

KW - PTP inhibitor

KW - Type 2 diabetes

UR - https://www.scopus.com/pages/publications/85101446557

U2 - 10.1007/s12272-021-01315-9

DO - 10.1007/s12272-021-01315-9

M3 - Review article

C2 - 33590390

AN - SCOPUS:85101446557

SN - 0253-6269

VL - 44

SP - 310

EP - 321

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities

Abstract

Keywords

UN SDGs

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