Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region

Joo Ho Shin; Talin Gulesserian; Emmanuelle Verger; Jean Maurice Delabar; Gert Lubec

doi:10.1021/pr050235f

Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region

Joo Ho Shin
, Talin Gulesserian
, Emmanuelle Verger
, Jean Maurice Delabar
, Gert Lubec

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.

Original language	English
Pages (from-to)	44-53
Number of pages	10
Journal	Journal of Proteome Research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1021/pr050235f
State	Published - Jan 2006
Externally published	Yes

Keywords

Chromosome 21
Down Syndrome critical region
Hippocampus
Polytransgenic mice
Two-dimensional gel electrophoresis

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10.1021/pr050235f

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title = "Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region",

abstract = "Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.",

keywords = "Chromosome 21, Down Syndrome critical region, Hippocampus, Polytransgenic mice, Two-dimensional gel electrophoresis",

author = "Shin, \{Joo Ho\} and Talin Gulesserian and Emmanuelle Verger and Delabar, \{Jean Maurice\} and Gert Lubec",

year = "2006",

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T1 - Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region

AU - Shin, Joo Ho

AU - Gulesserian, Talin

AU - Verger, Emmanuelle

AU - Delabar, Jean Maurice

AU - Lubec, Gert

PY - 2006/1

Y1 - 2006/1

N2 - Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.

AB - Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.

KW - Chromosome 21

KW - Down Syndrome critical region

KW - Hippocampus

KW - Polytransgenic mice

KW - Two-dimensional gel electrophoresis

UR - https://www.scopus.com/pages/publications/30744441654

U2 - 10.1021/pr050235f

DO - 10.1021/pr050235f

M3 - Article

C2 - 16396494

AN - SCOPUS:30744441654

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JO - Journal of Proteome Research

JF - Journal of Proteome Research

IS - 1

ER -

Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region

Abstract

Keywords

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