Proposed new staging system for ampulla of Vater cancer with greater discriminatory ability: multinational study from eastern and western centers

Background: We built a multinational retrospective database of patients with ampulla of Vater cancer to develop a reliable new staging system. Method: This study included 841 patients with ampulla of Vater cancer after curative surgery at Seoul National University Hospital (n = 440) and Johns Hopkins University medical institutions (n = 401) between 1985 and 2013. Results: The 5-year overall survival (OS) rates of patients staged according to the 7^th American Joint Committee on Cancer staging system were 80.3%, 60.9%, 58.1%, 36.6%, 17.9%, and 25.0% for Stages IA (n = 140), IB (n = 194), IIA (n = 115), IIB (n = 348), III (n = 33), and IV (n = 4), respectively. Five-year OS rates were similar in patients with Stage IB (T2N0M0) and IIA (T3N0M0) tumors (P = 0.556), but differed significantly between other pairs of groups. The number of positive lymph nodes (PLN) enhanced prognosis when stratified as 0, 1–2 and ≥3 (P < 0.001). The revised staging system consisted of Stages I (T1, PLN 0), IIA (T2–T3, PLN 0), IIB (T1–T3, PLN 1–2), III (PLN ≥3 or any T4), and IV (any M1), with 5-year OS rates differing significantly in each pair of groups, including Stages I and IIA (P < 0.001). Conclusion: This new staging system has better discriminatory ability in stratifying 5-year OS rates based on a large multinational database.