Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

William H. Hudson; Julia Gensheimer; Masao Hashimoto; Andreas Wieland; Rajesh M. Valanparambil; Peng Li; Jian Xin Lin; Bogumila T. Konieczny; Se Jin Im; Gordon J. Freeman; Warren J. Leonard; Haydn T. Kissick; Rafi Ahmed

doi:10.1016/j.immuni.2019.11.002

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic Infection

William H. Hudson
, Julia Gensheimer
, Masao Hashimoto
, Andreas Wieland
, Rajesh M. Valanparambil
, Peng Li
, Jian Xin Lin
, Bogumila T. Konieczny
, Se Jin Im
, Gordon J. Freeman
, Warren J. Leonard
, Haydn T. Kissick
, Rafi Ahmed

Emory University
National Institutes of Health
Dana-Farber Cancer Institute

Research output: Contribution to journal › Article › peer-review

523 Scopus citations

Abstract

Chronic viral infection induces exhaustion of antigen-specific T cells. Hudson and colleagues define a transitory, effector-like population of CD8⁺ T cells that are recently generated from stem-like CD8⁺ T cells in chronic infection. These transitory cells contribute to viral control and are increased in number following PD-1 pathway blockade.

Original language	English
Pages (from-to)	1043-1058.e4
Journal	Immunity
Volume	51
Issue number	6
DOIs	https://doi.org/10.1016/j.immuni.2019.11.002
State	Published - 17 Dec 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CD101
CD8 T cells
CX3CR1
LCMV
PD-1
T cell differentiation
checkpoint blockade
chronic viral infection
exhaustion
immunotherapy

Access to Document

10.1016/j.immuni.2019.11.002

Cite this

Hudson, W. H., Gensheimer, J., Hashimoto, M., Wieland, A., Valanparambil, R. M., Li, P., Lin, J. X., Konieczny, B. T., Im, S. J., Freeman, G. J., Leonard, W. J., Kissick, H. T., & Ahmed, R. (2019). Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic Infection. Immunity, 51(6), 1043-1058.e4. https://doi.org/10.1016/j.immuni.2019.11.002

@article{9572ee8ca5264c58984fda26bb2ccb90,

title = "Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection",

abstract = "Chronic viral infection induces exhaustion of antigen-specific T cells. Hudson and colleagues define a transitory, effector-like population of CD8+ T cells that are recently generated from stem-like CD8+ T cells in chronic infection. These transitory cells contribute to viral control and are increased in number following PD-1 pathway blockade.",

keywords = "CD101, CD8 T cells, CX3CR1, LCMV, PD-1, T cell differentiation, checkpoint blockade, chronic viral infection, exhaustion, immunotherapy",

author = "Hudson, \{William H.\} and Julia Gensheimer and Masao Hashimoto and Andreas Wieland and Valanparambil, \{Rajesh M.\} and Peng Li and Lin, \{Jian Xin\} and Konieczny, \{Bogumila T.\} and Im, \{Se Jin\} and Freeman, \{Gordon J.\} and Leonard, \{Warren J.\} and Kissick, \{Haydn T.\} and Rafi Ahmed",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "17",

doi = "10.1016/j.immuni.2019.11.002",

language = "English",

volume = "51",

pages = "1043--1058.e4",

journal = "Immunity",

issn = "1074-7613",

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number = "6",

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Hudson, WH, Gensheimer, J, Hashimoto, M, Wieland, A, Valanparambil, RM, Li, P, Lin, JX, Konieczny, BT, Im, SJ, Freeman, GJ, Leonard, WJ, Kissick, HT & Ahmed, R 2019, 'Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic Infection', Immunity, vol. 51, no. 6, pp. 1043-1058.e4. https://doi.org/10.1016/j.immuni.2019.11.002

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T1 - Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

AU - Hudson, William H.

AU - Gensheimer, Julia

AU - Hashimoto, Masao

AU - Wieland, Andreas

AU - Valanparambil, Rajesh M.

AU - Li, Peng

AU - Lin, Jian Xin

AU - Konieczny, Bogumila T.

AU - Im, Se Jin

AU - Freeman, Gordon J.

AU - Leonard, Warren J.

AU - Kissick, Haydn T.

AU - Ahmed, Rafi

PY - 2019/12/17

Y1 - 2019/12/17

N2 - Chronic viral infection induces exhaustion of antigen-specific T cells. Hudson and colleagues define a transitory, effector-like population of CD8+ T cells that are recently generated from stem-like CD8+ T cells in chronic infection. These transitory cells contribute to viral control and are increased in number following PD-1 pathway blockade.

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KW - CD101

KW - CD8 T cells

KW - CX3CR1

KW - LCMV

KW - PD-1

KW - T cell differentiation

KW - checkpoint blockade

KW - chronic viral infection

KW - exhaustion

KW - immunotherapy

UR - https://www.scopus.com/pages/publications/85076168642

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DO - 10.1016/j.immuni.2019.11.002

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SN - 1074-7613

VL - 51

SP - 1043-1058.e4

JO - Immunity

JF - Immunity

IS - 6

ER -