Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

Juyoun Jin; Woo Sirl Lee; Kyeung Min Joo; Kaustabh K. Maiti; Goutam Biswas; Wanil Kim; Kyong Tai Kim; Se Jeong Lee; Kang Ho Kim; Do Hyun Nam; Sung Kee Chung

doi:10.1039/c0md00235f

Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

Juyoun Jin
, Woo Sirl Lee
, Kyeung Min Joo
, Kaustabh K. Maiti
, Goutam Biswas
, Wanil Kim
, Kyong Tai Kim
, Se Jeong Lee
, Kang Ho Kim
, Do Hyun Nam
, Sung Kee Chung

Department of Neurosurgery

Pohang University of Science and Technology
Seoul National University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.

Original language	English
Pages (from-to)	270-273
Number of pages	4
Journal	MedChemComm
Volume	2
Issue number	4
DOIs	https://doi.org/10.1039/c0md00235f
State	Published - Apr 2011

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c0md00235f

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title = "Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model",

abstract = "The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.",

author = "Juyoun Jin and Lee, \{Woo Sirl\} and Joo, \{Kyeung Min\} and Maiti, \{Kaustabh K.\} and Goutam Biswas and Wanil Kim and Kim, \{Kyong Tai\} and Lee, \{Se Jeong\} and Kim, \{Kang Ho\} and Nam, \{Do Hyun\} and Chung, \{Sung Kee\}",

year = "2011",

month = apr,

doi = "10.1039/c0md00235f",

language = "English",

volume = "2",

pages = "270--273",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

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T1 - Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

AU - Jin, Juyoun

AU - Lee, Woo Sirl

AU - Joo, Kyeung Min

AU - Maiti, Kaustabh K.

AU - Biswas, Goutam

AU - Kim, Wanil

AU - Kim, Kyong Tai

AU - Lee, Se Jeong

AU - Kim, Kang Ho

AU - Nam, Do Hyun

AU - Chung, Sung Kee

PY - 2011/4

Y1 - 2011/4

N2 - The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.

AB - The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.

UR - https://www.scopus.com/pages/publications/79953873279

U2 - 10.1039/c0md00235f

DO - 10.1039/c0md00235f

M3 - Article

AN - SCOPUS:79953873279

SN - 2040-2503

VL - 2

SP - 270

EP - 273

JO - MedChemComm

JF - MedChemComm

IS - 4

ER -

Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

Abstract

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