Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea

Kwan Soo Ko; Ji Young Lee; Jin Yang Baek; Ji Yoeun Suh; Mi Young Lee; Ji Young Choi; Joon Sup Yeom; Yeon Sook Kim; Sook In Jung; Sang Yop Shin; Sang Taek Heo; Ki Tae Kwon; Jun Seong Son; Shin Woo Kim; Hyun Ha Chang; Hyun Kyun Ki; Doo Ryeon Chung; Kyong Ran Peck; Jae Hoon Song

doi:10.1099/jmm.0.018119-0

Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea

Kwan Soo Ko
, Ji Young Lee
, Jin Yang Baek
, Ji Yoeun Suh
, Mi Young Lee
, Ji Young Choi
, Joon Sup Yeom
, Yeon Sook Kim
, Sook In Jung
, Sang Yop Shin
, Sang Taek Heo
, Ki Tae Kwon
, Jun Seong Son
, Shin Woo Kim
, Hyun Ha Chang
, Hyun Kyun Ki
, Doo Ryeon Chung
, Kyong Ran Peck
, Jae Hoon Song

Sungkyunkwan University
Asian-Pacific Research Foundation for Infectious Diseases (ARFID)
Kangbuk Samsung Hospital
Chungnam National University
Chonnam National University
Jeju National University
Gyeongsang National University
Daegu Fatima Hospital
Kyung Hee University
Kyungpook National University
Konkuk University

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

To investigate the antimicrobial resistance, extended-spectrum β-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates) were collected from 10 tertiary-care Korean hospitals from July 2006 to October 2007. In vitro antimicrobial susceptibility testing was performed for all isolates and ESBL production was tested. Multilocus sequence typing (MLST) analyses were performed to characterize genotypes of ESBL-producing K. pneumoniae isolates. PFGE was performed for sequence type 11 (ST11) isolates. Forty-seven UTI isolates (25.4 %) produced ESBLs, while 30 bacteraemia isolates (13.6 %) produced ESBLs (P=0.002). Among 77 ESBL-producing isolates, thirty-two (41.6 %) produced SHV-type ESBLs. bla_CTX-M genes such as bla _CTX-M-14 and bla_CTX-M-15 were detected in 36.4 %. MLST and PFGE analyses showed that ST11 was dominant in ESBL-producing K. pneumoniae isolates causing UTI (57.4 %) and in those causing bacteraemia (70.0 %) and has been prevalent in Korean hospitals. ST11 isolates harbour a combination of different ESBL genes. The ST11 clone of ESBL-producing K. pneumoniae isolates prevails in Korea, but most isolates might acquire ESBL genes independently or several different clones might be distributed in Korea.

Original language	English
Pages (from-to)	822-828
Number of pages	7
Journal	Journal of Medical Microbiology
Volume	59
Issue number	7
DOIs	https://doi.org/10.1099/jmm.0.018119-0
State	Published - Jul 2010

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Ko, K. S., Lee, J. Y., Baek, J. Y., Suh, J. Y., Lee, M. Y., Choi, J. Y., Yeom, J. S., Kim, Y. S., Jung, S. I., Shin, S. Y., Heo, S. T., Kwon, K. T., Son, J. S., Kim, S. W., Chang, H. H., Ki, H. K., Chung, D. R., Peck, K. R., & Song, J. H. (2010). Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea. Journal of Medical Microbiology, 59(7), 822-828. https://doi.org/10.1099/jmm.0.018119-0

@article{c50a6584e6b144cc9eae5422caf4987b,

title = "Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea",

abstract = "To investigate the antimicrobial resistance, extended-spectrum β-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates) were collected from 10 tertiary-care Korean hospitals from July 2006 to October 2007. In vitro antimicrobial susceptibility testing was performed for all isolates and ESBL production was tested. Multilocus sequence typing (MLST) analyses were performed to characterize genotypes of ESBL-producing K. pneumoniae isolates. PFGE was performed for sequence type 11 (ST11) isolates. Forty-seven UTI isolates (25.4 \%) produced ESBLs, while 30 bacteraemia isolates (13.6 \%) produced ESBLs (P=0.002). Among 77 ESBL-producing isolates, thirty-two (41.6 \%) produced SHV-type ESBLs. blaCTX-M genes such as bla CTX-M-14 and blaCTX-M-15 were detected in 36.4 \%. MLST and PFGE analyses showed that ST11 was dominant in ESBL-producing K. pneumoniae isolates causing UTI (57.4 \%) and in those causing bacteraemia (70.0 \%) and has been prevalent in Korean hospitals. ST11 isolates harbour a combination of different ESBL genes. The ST11 clone of ESBL-producing K. pneumoniae isolates prevails in Korea, but most isolates might acquire ESBL genes independently or several different clones might be distributed in Korea.",

author = "Ko, \{Kwan Soo\} and Lee, \{Ji Young\} and Baek, \{Jin Yang\} and Suh, \{Ji Yoeun\} and Lee, \{Mi Young\} and Choi, \{Ji Young\} and Yeom, \{Joon Sup\} and Kim, \{Yeon Sook\} and Jung, \{Sook In\} and Shin, \{Sang Yop\} and Heo, \{Sang Taek\} and Kwon, \{Ki Tae\} and Son, \{Jun Seong\} and Kim, \{Shin Woo\} and Chang, \{Hyun Ha\} and Ki, \{Hyun Kyun\} and Chung, \{Doo Ryeon\} and Peck, \{Kyong Ran\} and Song, \{Jae Hoon\}",

year = "2010",

month = jul,

doi = "10.1099/jmm.0.018119-0",

language = "English",

volume = "59",

pages = "822--828",

journal = "Journal of Medical Microbiology",

issn = "0022-2615",

publisher = "Microbiology Society",

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Ko, KS, Lee, JY, Baek, JY, Suh, JY, Lee, MY, Choi, JY, Yeom, JS, Kim, YS, Jung, SI, Shin, SY, Heo, ST, Kwon, KT, Son, JS, Kim, SW, Chang, HH, Ki, HK, Chung, DR , Peck, KR & Song, JH 2010, 'Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea', Journal of Medical Microbiology, vol. 59, no. 7, pp. 822-828. https://doi.org/10.1099/jmm.0.018119-0

TY - JOUR

T1 - Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea

AU - Ko, Kwan Soo

AU - Lee, Ji Young

AU - Baek, Jin Yang

AU - Suh, Ji Yoeun

AU - Lee, Mi Young

AU - Choi, Ji Young

AU - Yeom, Joon Sup

AU - Kim, Yeon Sook

AU - Jung, Sook In

AU - Shin, Sang Yop

AU - Heo, Sang Taek

AU - Kwon, Ki Tae

AU - Son, Jun Seong

AU - Kim, Shin Woo

AU - Chang, Hyun Ha

AU - Ki, Hyun Kyun

AU - Chung, Doo Ryeon

AU - Peck, Kyong Ran

AU - Song, Jae Hoon

PY - 2010/7

Y1 - 2010/7

N2 - To investigate the antimicrobial resistance, extended-spectrum β-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates) were collected from 10 tertiary-care Korean hospitals from July 2006 to October 2007. In vitro antimicrobial susceptibility testing was performed for all isolates and ESBL production was tested. Multilocus sequence typing (MLST) analyses were performed to characterize genotypes of ESBL-producing K. pneumoniae isolates. PFGE was performed for sequence type 11 (ST11) isolates. Forty-seven UTI isolates (25.4 %) produced ESBLs, while 30 bacteraemia isolates (13.6 %) produced ESBLs (P=0.002). Among 77 ESBL-producing isolates, thirty-two (41.6 %) produced SHV-type ESBLs. blaCTX-M genes such as bla CTX-M-14 and blaCTX-M-15 were detected in 36.4 %. MLST and PFGE analyses showed that ST11 was dominant in ESBL-producing K. pneumoniae isolates causing UTI (57.4 %) and in those causing bacteraemia (70.0 %) and has been prevalent in Korean hospitals. ST11 isolates harbour a combination of different ESBL genes. The ST11 clone of ESBL-producing K. pneumoniae isolates prevails in Korea, but most isolates might acquire ESBL genes independently or several different clones might be distributed in Korea.

AB - To investigate the antimicrobial resistance, extended-spectrum β-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates) were collected from 10 tertiary-care Korean hospitals from July 2006 to October 2007. In vitro antimicrobial susceptibility testing was performed for all isolates and ESBL production was tested. Multilocus sequence typing (MLST) analyses were performed to characterize genotypes of ESBL-producing K. pneumoniae isolates. PFGE was performed for sequence type 11 (ST11) isolates. Forty-seven UTI isolates (25.4 %) produced ESBLs, while 30 bacteraemia isolates (13.6 %) produced ESBLs (P=0.002). Among 77 ESBL-producing isolates, thirty-two (41.6 %) produced SHV-type ESBLs. blaCTX-M genes such as bla CTX-M-14 and blaCTX-M-15 were detected in 36.4 %. MLST and PFGE analyses showed that ST11 was dominant in ESBL-producing K. pneumoniae isolates causing UTI (57.4 %) and in those causing bacteraemia (70.0 %) and has been prevalent in Korean hospitals. ST11 isolates harbour a combination of different ESBL genes. The ST11 clone of ESBL-producing K. pneumoniae isolates prevails in Korea, but most isolates might acquire ESBL genes independently or several different clones might be distributed in Korea.

UR - https://www.scopus.com/pages/publications/77954463665

U2 - 10.1099/jmm.0.018119-0

DO - 10.1099/jmm.0.018119-0

M3 - Article

C2 - 20360396

AN - SCOPUS:77954463665

SN - 0022-2615

VL - 59

SP - 822

EP - 828

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

IS - 7

ER -

Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea

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