Prdm4 induction by the small molecule butein promotes white adipose tissue browning

No Joon Song; Seri Choi; Prashant Rajbhandari; Seo Hyuk Chang; Suji Kim; Laurent Vergnes; So Mi Kwon; Jung Hoon Yoon; Sukchan Lee; Jin Mo Ku; Jeong Soo Lee; Karen Reue; Seung Hoi Koo; Peter Tontonoz; Kye Won Park

doi:10.1038/nchembio.2081

Prdm4 induction by the small molecule butein promotes white adipose tissue browning

No Joon Song
, Seri Choi
, Prashant Rajbhandari
, Seo Hyuk Chang
, Suji Kim
, Laurent Vergnes
, So Mi Kwon
, Jung Hoon Yoon
, Sukchan Lee
, Jin Mo Ku
, Jeong Soo Lee
, Karen Reue
, Seung Hoi Koo
, Peter Tontonoz
, Kye Won Park

Sungkyunkwan University
Korea University
University of California at Los Angeles
Gyeonggi Bio-Center
Korea Research Institute of Bioscience and Biotechnology
University of Science and Technology UST

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

Original language	English
Pages (from-to)	479-481
Number of pages	3
Journal	Nature Chemical Biology
Volume	12
Issue number	7
DOIs	https://doi.org/10.1038/nchembio.2081
State	Published - 1 Jul 2016

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SDG 3 Good Health and Well-being

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10.1038/nchembio.2081

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abstract = "Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.",

author = "Song, \{No Joon\} and Seri Choi and Prashant Rajbhandari and Chang, \{Seo Hyuk\} and Suji Kim and Laurent Vergnes and Kwon, \{So Mi\} and Yoon, \{Jung Hoon\} and Sukchan Lee and Ku, \{Jin Mo\} and Lee, \{Jeong Soo\} and Karen Reue and Koo, \{Seung Hoi\} and Peter Tontonoz and Park, \{Kye Won\}",

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doi = "10.1038/nchembio.2081",

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AU - Song, No Joon

AU - Choi, Seri

AU - Rajbhandari, Prashant

AU - Chang, Seo Hyuk

AU - Kim, Suji

AU - Vergnes, Laurent

AU - Kwon, So Mi

AU - Yoon, Jung Hoon

AU - Lee, Sukchan

AU - Ku, Jin Mo

AU - Lee, Jeong Soo

AU - Reue, Karen

AU - Koo, Seung Hoi

AU - Tontonoz, Peter

AU - Park, Kye Won

PY - 2016/7/1

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N2 - Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

AB - Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

UR - https://www.scopus.com/pages/publications/84966621800

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AN - SCOPUS:84966621800

SN - 1552-4450

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SP - 479

EP - 481

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 7

ER -

Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Abstract

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