Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2

Yeong Geun Lee; Kyung Won Kang; Woojae Hong; Yeon Hwa Kim; Jen Taek Oh; Dae Won Park; Minsung Ko; Yun Feng Bai; Young Jin Seo; Sang Myeong Lee; Hyunggun Kim; Se Chan Kang

doi:10.1016/j.bmc.2021.116329

Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2

Yeong Geun Lee
, Kyung Won Kang
, Woojae Hong
, Yeon Hwa Kim
, Jen Taek Oh
, Dae Won Park
, Minsung Ko
, Yun Feng Bai
, Young Jin Seo
, Sang Myeong Lee
, Hyunggun Kim
, Se Chan Kang

Department of Bio-Mechatronic Engineering

Kyung Hee University
Jeonbuk National University
Sungkyunkwan University
China Zhonggunacun Precision Medicine Science and Technology Foundation of Hepatology Center
Chung-Ang University
Chungbuk National University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.

Original language	English
Article number	116329
Journal	Bioorganic and Medicinal Chemistry
Volume	45
DOIs	https://doi.org/10.1016/j.bmc.2021.116329
State	Published - 1 Sep 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Agrimonia pilosa
Antiviral agents
APRG64
COVID-19
Galla rhois
SARS-CoV-2

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10.1016/j.bmc.2021.116329

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@article{88755611d585404dbd9f190768fad695,

title = "Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2",

abstract = "Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.",

keywords = "Agrimonia pilosa, Antiviral agents, APRG64, COVID-19, Galla rhois, SARS-CoV-2",

author = "Lee, \{Yeong Geun\} and Kang, \{Kyung Won\} and Woojae Hong and Kim, \{Yeon Hwa\} and Oh, \{Jen Taek\} and Park, \{Dae Won\} and Minsung Ko and Bai, \{Yun Feng\} and Seo, \{Young Jin\} and Lee, \{Sang Myeong\} and Hyunggun Kim and Kang, \{Se Chan\}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = sep,

day = "1",

doi = "10.1016/j.bmc.2021.116329",

language = "English",

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T1 - Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2

AU - Lee, Yeong Geun

AU - Kang, Kyung Won

AU - Hong, Woojae

AU - Kim, Yeon Hwa

AU - Oh, Jen Taek

AU - Park, Dae Won

AU - Ko, Minsung

AU - Bai, Yun Feng

AU - Seo, Young Jin

AU - Lee, Sang Myeong

AU - Kim, Hyunggun

AU - Kang, Se Chan

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.

AB - Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.

KW - Agrimonia pilosa

KW - Antiviral agents

KW - APRG64

KW - COVID-19

KW - Galla rhois

KW - SARS-CoV-2

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DO - 10.1016/j.bmc.2021.116329

M3 - Article

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AN - SCOPUS:85111225642

SN - 0968-0896

VL - 45

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

M1 - 116329

ER -

Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2

Abstract

UN SDGs

Keywords

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