Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity

Young Woock Noh; Ji Hyun Hong; Sang Mu Shim; Hye Sun Park; Hee Ho Bae; Eun Kyoung Ryu; Jung Hwan Hwang; Chul Ho Lee; Seong Hun Cho; Moon Hee Sung; Haryoung Poo; Yong Taik Lim

doi:10.1002/anie.201302881

Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity

Young Woock Noh
, Ji Hyun Hong
, Sang Mu Shim
, Hye Sun Park
, Hee Ho Bae
, Eun Kyoung Ryu
, Jung Hwan Hwang
, Chul Ho Lee
, Seong Hun Cho
, Moon Hee Sung
, Haryoung Poo
, Yong Taik Lim

Chungnam National University
Korea Research Institute of Bioscience and Biotechnology
Korea Basic Science Institute
Kookmin University
Bioleaders Corporation

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see picture).

Original language	English
Pages (from-to)	7684-7689
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	30
DOIs	https://doi.org/10.1002/anie.201302881
State	Published - 22 Jul 2013
Externally published	Yes

Keywords

antigen
mucosal immunity
mucus delivery
nanomicelles
nanoparticles

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10.1002/anie.201302881

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title = "Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity",

abstract = "Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see picture).",

keywords = "antigen, mucosal immunity, mucus delivery, nanomicelles, nanoparticles",

author = "Noh, \{Young Woock\} and Hong, \{Ji Hyun\} and Shim, \{Sang Mu\} and Park, \{Hye Sun\} and Bae, \{Hee Ho\} and Ryu, \{Eun Kyoung\} and Hwang, \{Jung Hwan\} and Lee, \{Chul Ho\} and Cho, \{Seong Hun\} and Sung, \{Moon Hee\} and Haryoung Poo and Lim, \{Yong Taik\}",

year = "2013",

month = jul,

day = "22",

doi = "10.1002/anie.201302881",

language = "English",

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pages = "7684--7689",

journal = "Angewandte Chemie - International Edition",

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T1 - Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity

AU - Noh, Young Woock

AU - Hong, Ji Hyun

AU - Shim, Sang Mu

AU - Park, Hye Sun

AU - Bae, Hee Ho

AU - Ryu, Eun Kyoung

AU - Hwang, Jung Hwan

AU - Lee, Chul Ho

AU - Cho, Seong Hun

AU - Sung, Moon Hee

AU - Poo, Haryoung

AU - Lim, Yong Taik

PY - 2013/7/22

Y1 - 2013/7/22

N2 - Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see picture).

AB - Micelles for mucosal immunity: A mucosal vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the vaccine system induces a high immune response both in the humoral and cellular immunity (see picture).

KW - antigen

KW - mucosal immunity

KW - mucus delivery

KW - nanomicelles

KW - nanoparticles

UR - https://www.scopus.com/pages/publications/84880344178

U2 - 10.1002/anie.201302881

DO - 10.1002/anie.201302881

M3 - Article

C2 - 23765547

AN - SCOPUS:84880344178

SN - 1433-7851

VL - 52

SP - 7684

EP - 7689

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 30

ER -

Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity

Abstract

Keywords

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