Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

Seoung Rak Lee; Felix Schalk; Jan W. Schwitalla; René Benndorf; John Vollmers; Anne Kristin Kaster; Z. Wilhelm De Beer; Minji Park; Mi Jeong Ahn; Won Hee Jung; Christine Beemelmanns; Ki Hyun Kim

doi:10.1021/acs.jnatprod.0c00676

Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

Seoung Rak Lee
, Felix Schalk
, Jan W. Schwitalla
, René Benndorf
, John Vollmers
, Anne Kristin Kaster
, Z. Wilhelm De Beer
, Minji Park
, Mi Jeong Ahn
, Won Hee Jung
, Christine Beemelmanns
, Ki Hyun Kim

Department of Pharmacy

Sungkyunkwan University
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
Karlsruhe Institute of Technology
University of Pretoria
Chung-Ang University
Gyeongsang National University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.

Original language	English
Pages (from-to)	3102-3110
Number of pages	9
Journal	Journal of Natural Products
Volume	83
Issue number	10
DOIs	https://doi.org/10.1021/acs.jnatprod.0c00676
State	Published - 23 Oct 2020

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title = "Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99",

abstract = "Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.",

author = "\{Rak Lee\}, Seoung and Felix Schalk and Schwitalla, \{Jan W.\} and Ren{\'e} Benndorf and John Vollmers and Kaster, \{Anne Kristin\} and \{De Beer\}, \{Z. Wilhelm\} and Minji Park and Ahn, \{Mi Jeong\} and Jung, \{Won Hee\} and Christine Beemelmanns and Kim, \{Ki Hyun\}",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society and American Society of Pharmacognosy.",

year = "2020",

month = oct,

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doi = "10.1021/acs.jnatprod.0c00676",

language = "English",

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T1 - Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

AU - Rak Lee, Seoung

AU - Schalk, Felix

AU - Schwitalla, Jan W.

AU - Benndorf, René

AU - Vollmers, John

AU - Kaster, Anne Kristin

AU - De Beer, Z. Wilhelm

AU - Park, Minji

AU - Ahn, Mi Jeong

AU - Jung, Won Hee

AU - Beemelmanns, Christine

AU - Kim, Ki Hyun

PY - 2020/10/23

Y1 - 2020/10/23

N2 - Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.

AB - Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.

UR - https://www.scopus.com/pages/publications/85092037142

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DO - 10.1021/acs.jnatprod.0c00676

M3 - Article

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AN - SCOPUS:85092037142

SN - 0163-3864

VL - 83

SP - 3102

EP - 3110

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

Abstract

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