Placental deposition of C-reactive protein is a common feature of human pregnancy

E. N. Kim; B. H. Yoon; E. J. Jeon; J. B. Lee; J. S. Hong; J. Y. Lee; D. Hwang; K. C. Kim; J. S. Kim; C. J. Kim

doi:10.1016/j.placenta.2015.03.006

Placental deposition of C-reactive protein is a common feature of human pregnancy

E. N. Kim, B. H. Yoon, E. J. Jeon, J. B. Lee, J. S. Hong, J. Y. Lee, D. Hwang, K. C. Kim, J. S. Kim, C. J. Kim

Department of Pathology and Translational Genomics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.

Original language	English
Pages (from-to)	704-707
Number of pages	4
Journal	Placenta
Volume	36
Issue number	6
DOIs	https://doi.org/10.1016/j.placenta.2015.03.006
State	Published - 1 Jun 2015

Keywords

C-reactive protein
Immunohistochemistry
Placenta
Trophoblast

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.placenta.2015.03.006

Cite this

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title = "Placental deposition of C-reactive protein is a common feature of human pregnancy",

abstract = "This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.",

keywords = "C-reactive protein, Immunohistochemistry, Placenta, Trophoblast",

author = "Kim, \{E. N.\} and Yoon, \{B. H.\} and Jeon, \{E. J.\} and Lee, \{J. B.\} and Hong, \{J. S.\} and Lee, \{J. Y.\} and D. Hwang and Kim, \{K. C.\} and Kim, \{J. S.\} and Kim, \{C. J.\}",

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year = "2015",

month = jun,

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doi = "10.1016/j.placenta.2015.03.006",

language = "English",

volume = "36",

pages = "704--707",

journal = "Placenta",

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TY - JOUR

T1 - Placental deposition of C-reactive protein is a common feature of human pregnancy

AU - Kim, E. N.

AU - Yoon, B. H.

AU - Jeon, E. J.

AU - Lee, J. B.

AU - Hong, J. S.

AU - Lee, J. Y.

AU - Hwang, D.

AU - Kim, K. C.

AU - Kim, J. S.

AU - Kim, C. J.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.

AB - This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.

KW - C-reactive protein

KW - Immunohistochemistry

KW - Placenta

KW - Trophoblast

UR - https://www.scopus.com/pages/publications/84929653800

U2 - 10.1016/j.placenta.2015.03.006

DO - 10.1016/j.placenta.2015.03.006

M3 - Article

C2 - 25817719

AN - SCOPUS:84929653800

SN - 0143-4004

VL - 36

SP - 704

EP - 707

JO - Placenta

JF - Placenta

IS - 6

ER -

Placental deposition of C-reactive protein is a common feature of human pregnancy

Abstract

Keywords

UN SDGs

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