Phytochemical constituents of Salsola komarovii and their effects on NGF induction

Five lignan glycosides, seven megastigmane glycosides, and seven phenolic compounds were isolated by repeated column chromatography from the MeOH extract of Salsola komarovii. Their structures were determined to be lariciresinol-9-O-β-D-glucopyranoside (1), alangilignoside C (2), conicaoside (3), (+)- lyoniresinol 9'-O-β-D-glucopyranoside (4), (8S,8'R,7'R)-9'-[(β-glucopyranosyl)oxy]lyoniresinol (5), blumenyl B β- D-glucopyranoside (6), blumenyl A β-D-glucopyranoside (7), staphylionoside D (8), icariside B2 (9), (6R,9S)-3- oxo-α-ionol β-D-glucopyranoside (10), 3-oxo-α-ionol 9-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (11), blumenol B 9-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (12), benzyl 6-O-β-D-apiofuranosyl-β-Dglucopyranoside (13), canthoside C (14), tachioside (15), isotachioside (16), biophenol 2 (17), 2-(3,4-dihydroxy)- phenyl-ethyl-β-D-glucopyranoside (18), and cuneataside C (19) by spectroscopic methods. All the isolated compounds 1 - 19 were reported from this source for the first time. Compounds 2, 3 and 6 upregulated NGF secretion to 118.8 ± 3.6%, 128.2 ± 9.3% and 111.1 ± 7.1% without significant cell toxicity.