Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren

Eun Kyo Ha; Ju Hee Kim; Dawon Park; Eun Lee; Seung Won Lee; Hye Mi Jee; Youn Ho Shin; Man Yong Han

doi:10.3346/JKMS.2022.37.E63

Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren

Eun Kyo Ha
, Ju Hee Kim
, Dawon Park
, Eun Lee
, Seung Won Lee
, Hye Mi Jee
, Youn Ho Shin
, Man Yong Han

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren.Methods: Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children.Results: Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results.Conclusion:

Original language	English
Article number	e63
Journal	Journal of Korean Medical Science
Volume	37
Issue number	8
DOIs	https://doi.org/10.3346/JKMS.2022.37.E63
State	Published - 2022
Externally published	Yes

Keywords

Atopic dermatitis
Urinary metabolite
Volatile organic compounds

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3346/JKMS.2022.37.E63

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title = "Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren",

abstract = "Background: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren.Methods: Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children.Results: Forty-five children (30.2\%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8\%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results.Conclusion:",

keywords = "Atopic dermatitis, Urinary metabolite, Volatile organic compounds",

author = "Ha, \{Eun Kyo\} and Kim, \{Ju Hee\} and Dawon Park and Eun Lee and Lee, \{Seung Won\} and Jee, \{Hye Mi\} and Shin, \{Youn Ho\} and Han, \{Man Yong\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Korean Academy of Medical Sciences",

year = "2022",

doi = "10.3346/JKMS.2022.37.E63",

language = "English",

volume = "37",

journal = "Journal of Korean Medical Science",

issn = "1011-8934",

publisher = "Korean Academy of Medical Science",

number = "8",

}

TY - JOUR

T1 - Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren

AU - Ha, Eun Kyo

AU - Kim, Ju Hee

AU - Park, Dawon

AU - Lee, Eun

AU - Lee, Seung Won

AU - Jee, Hye Mi

AU - Shin, Youn Ho

AU - Han, Man Yong

PY - 2022

Y1 - 2022

N2 - Background: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren.Methods: Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children.Results: Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results.Conclusion:

AB - Background: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren.Methods: Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children.Results: Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results.Conclusion:

KW - Atopic dermatitis

KW - Urinary metabolite

KW - Volatile organic compounds

UR - https://www.scopus.com/pages/publications/85125431726

U2 - 10.3346/JKMS.2022.37.E63

DO - 10.3346/JKMS.2022.37.E63

M3 - Article

C2 - 35226421

AN - SCOPUS:85125431726

SN - 1011-8934

VL - 37

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 8

M1 - e63

ER -

Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren

Abstract

Keywords

UN SDGs

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