PdH-Electrocatalytic Formal Conjugate Fluorination of β-Aryl-α,β-Unsaturated Amides with Mild and Safe Nucleophilic Fluorine Sources

An electrooxidative palladium-hydride catalytic system has been developed for the hydrofluorination of β-aryl-α,β-unsaturated amides using various nucleophilic fluorine sources, including Me₄NF, Me₄NF·tAmylOH, nBu₄NF·(tBuOH)₄, CsF, and KF. By avoiding hazardous HF-based reagents, this electrocatalytic protocol offers a safer and more practical route for the formal conjugate addition of fluoride to β-aryl-α,β-unsaturated amides, enabling access to β-fluoroamides. The method exhibits broad functional group tolerance, as exemplified by its application to the late-stage derivatization of complex molecules.