Patterned Poly(dopamine) films for enhanced cell adhesion

Xi Chen; Christina Cortez-Jugo; Gwan H. Choi; Mattias Björnmalm; Yunlu Dai; Pil J. Yoo; Frank Caruso

doi:10.1021/acs.bioconjchem.6b00544

Patterned Poly(dopamine) films for enhanced cell adhesion

Xi Chen, Christina Cortez-Jugo, Gwan H. Choi, Mattias Björnmalm, Yunlu Dai, Pil J. Yoo, Frank Caruso

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In this work, we produced poly(dopamine) (PDA) films with engineered patterns for improved cell adhesion. The patterned films were synthesized via the polymerization of dopamine at the air-water interface of a floating bed of spherical particles. Subsequent dissolution of the particles yielded free-standing PDA films with tunable geometrical patterns. Our results show that these patterned PDA films significantly enhance the adhesion of both cancer cells and stem cells, thus showing promise as substrates for cell attachment for various biomedical applications.

Original language	English
Pages (from-to)	75-80
Number of pages	6
Journal	Bioconjugate Chemistry
Volume	28
Issue number	1
DOIs	https://doi.org/10.1021/acs.bioconjchem.6b00544
State	Published - 18 Jan 2017

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title = "Patterned Poly(dopamine) films for enhanced cell adhesion",

abstract = "Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In this work, we produced poly(dopamine) (PDA) films with engineered patterns for improved cell adhesion. The patterned films were synthesized via the polymerization of dopamine at the air-water interface of a floating bed of spherical particles. Subsequent dissolution of the particles yielded free-standing PDA films with tunable geometrical patterns. Our results show that these patterned PDA films significantly enhance the adhesion of both cancer cells and stem cells, thus showing promise as substrates for cell attachment for various biomedical applications.",

author = "Xi Chen and Christina Cortez-Jugo and Choi, \{Gwan H.\} and Mattias Bj{\"o}rnmalm and Yunlu Dai and Yoo, \{Pil J.\} and Frank Caruso",

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AU - Chen, Xi

AU - Cortez-Jugo, Christina

AU - Choi, Gwan H.

AU - Björnmalm, Mattias

AU - Dai, Yunlu

AU - Yoo, Pil J.

AU - Caruso, Frank

PY - 2017/1/18

Y1 - 2017/1/18

N2 - Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In this work, we produced poly(dopamine) (PDA) films with engineered patterns for improved cell adhesion. The patterned films were synthesized via the polymerization of dopamine at the air-water interface of a floating bed of spherical particles. Subsequent dissolution of the particles yielded free-standing PDA films with tunable geometrical patterns. Our results show that these patterned PDA films significantly enhance the adhesion of both cancer cells and stem cells, thus showing promise as substrates for cell attachment for various biomedical applications.

AB - Engineered materials that promote cell adhesion and cell growth are important in tissue engineering and regenerative medicine. In this work, we produced poly(dopamine) (PDA) films with engineered patterns for improved cell adhesion. The patterned films were synthesized via the polymerization of dopamine at the air-water interface of a floating bed of spherical particles. Subsequent dissolution of the particles yielded free-standing PDA films with tunable geometrical patterns. Our results show that these patterned PDA films significantly enhance the adhesion of both cancer cells and stem cells, thus showing promise as substrates for cell attachment for various biomedical applications.

UR - https://www.scopus.com/pages/publications/85021860331

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JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 1

ER -

Patterned Poly(dopamine) films for enhanced cell adhesion

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