Palladium-catalyzed decarboxylative acylation of O-phenyl carbamates with α-oxocarboxylic acids at room temperature

Satyasheel Sharma; Aejin Kim; Eonjeong Park; Jihye Park; Minyoung Kim; Jong Hwan Kwak; Sang Hwi Lee; Young Hoon Jung; In Su Kim

doi:10.1002/adsc.201200993

Palladium-catalyzed decarboxylative acylation of O-phenyl carbamates with α-oxocarboxylic acids at room temperature

Satyasheel Sharma
, Aejin Kim
, Eonjeong Park
, Jihye Park
, Minyoung Kim
, Jong Hwan Kwak
, Sang Hwi Lee
, Young Hoon Jung
, In Su Kim

Department of Pharmacy

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

A palladium-catalyzed oxidative acylation of O-phenyl carbamates with α-oxocarboxylic acids via selective aromatic C-H bond activation is described. This protocol represents the first ortho-acylation of phenol derivatives, and a catalytic amount of triflic acid additive is crucial for this transformation.

Original language	English
Pages (from-to)	667-672
Number of pages	6
Journal	Advanced Synthesis and Catalysis
Volume	355
Issue number	4
DOIs	https://doi.org/10.1002/adsc.201200993
State	Published - 11 Mar 2013

Keywords

α-oxocarboxylic acids
acylation
C-H activation
O-phenyl carbamates
palladium

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10.1002/adsc.201200993

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title = "Palladium-catalyzed decarboxylative acylation of O-phenyl carbamates with α-oxocarboxylic acids at room temperature",

abstract = "A palladium-catalyzed oxidative acylation of O-phenyl carbamates with α-oxocarboxylic acids via selective aromatic C-H bond activation is described. This protocol represents the first ortho-acylation of phenol derivatives, and a catalytic amount of triflic acid additive is crucial for this transformation.",

keywords = "α-oxocarboxylic acids, acylation, C-H activation, O-phenyl carbamates, palladium",

author = "Satyasheel Sharma and Aejin Kim and Eonjeong Park and Jihye Park and Minyoung Kim and Kwak, \{Jong Hwan\} and Lee, \{Sang Hwi\} and Jung, \{Young Hoon\} and Kim, \{In Su\}",

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T1 - Palladium-catalyzed decarboxylative acylation of O-phenyl carbamates with α-oxocarboxylic acids at room temperature

AU - Sharma, Satyasheel

AU - Kim, Aejin

AU - Park, Eonjeong

AU - Park, Jihye

AU - Kim, Minyoung

AU - Kwak, Jong Hwan

AU - Lee, Sang Hwi

AU - Jung, Young Hoon

AU - Kim, In Su

PY - 2013/3/11

Y1 - 2013/3/11

N2 - A palladium-catalyzed oxidative acylation of O-phenyl carbamates with α-oxocarboxylic acids via selective aromatic C-H bond activation is described. This protocol represents the first ortho-acylation of phenol derivatives, and a catalytic amount of triflic acid additive is crucial for this transformation.

AB - A palladium-catalyzed oxidative acylation of O-phenyl carbamates with α-oxocarboxylic acids via selective aromatic C-H bond activation is described. This protocol represents the first ortho-acylation of phenol derivatives, and a catalytic amount of triflic acid additive is crucial for this transformation.

KW - α-oxocarboxylic acids

KW - acylation

KW - C-H activation

KW - O-phenyl carbamates

KW - palladium

UR - https://www.scopus.com/pages/publications/84874668290

U2 - 10.1002/adsc.201200993

DO - 10.1002/adsc.201200993

M3 - Article

AN - SCOPUS:84874668290

SN - 1615-4150

VL - 355

SP - 667

EP - 672

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 4

ER -

Palladium-catalyzed decarboxylative acylation of O-phenyl carbamates with α-oxocarboxylic acids at room temperature

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Keywords

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