Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

Se Won Kim; Seung Eun Lee; Young Lyun Oh; Seokhwi Kim; Sun Hee Park; Jae Hyeon Kim

doi:10.1155/2016/5731417

Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

Se Won Kim, Seung Eun Lee, Young Lyun Oh, Seokhwi Kim, Sun Hee Park, Jae Hyeon Kim

Department of Pathology and Translational Genomics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

Original language	English
Article number	5731417
Journal	Case Reports in Endocrinology
Volume	2016
DOIs	https://doi.org/10.1155/2016/5731417
State	Published - 2016

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title = "Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma",

abstract = "Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.",

author = "Kim, \{Se Won\} and Lee, \{Seung Eun\} and Oh, \{Young Lyun\} and Seokhwi Kim and Park, \{Sun Hee\} and Kim, \{Jae Hyeon\}",

note = "Publisher Copyright: {\textcopyright} 2016 Se Won Kim et al.",

year = "2016",

doi = "10.1155/2016/5731417",

language = "English",

volume = "2016",

journal = "Case Reports in Endocrinology",

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T1 - Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

AU - Kim, Se Won

AU - Lee, Seung Eun

AU - Oh, Young Lyun

AU - Kim, Seokhwi

AU - Park, Sun Hee

AU - Kim, Jae Hyeon

PY - 2016

Y1 - 2016

N2 - Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

AB - Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

UR - https://www.scopus.com/pages/publications/85025065493

U2 - 10.1155/2016/5731417

DO - 10.1155/2016/5731417

M3 - Article

AN - SCOPUS:85025065493

SN - 2090-6501

VL - 2016

JO - Case Reports in Endocrinology

JF - Case Reports in Endocrinology

M1 - 5731417

ER -

Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

Abstract

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