Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery

Young Chul Cho; Wooram Park; Jeon Min Kang; Dae Sung Ryu; Yubeen Park; Jae Won Seo; Young Gook Koh; Jung Hoon Park; Ji Hoon Shin

doi:10.1007/s13233-021-9022-7

Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery

Young Chul Cho
, Wooram Park
, Jeon Min Kang
, Dae Sung Ryu
, Yubeen Park
, Jae Won Seo
, Young Gook Koh
, Jung Hoon Park
, Ji Hoon Shin

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases. [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	178-184
Number of pages	7
Journal	Macromolecular Research
Volume	29
Issue number	2
DOIs	https://doi.org/10.1007/s13233-021-9022-7
State	Published - Feb 2021
Externally published	Yes

Keywords

arterial diseases
embolic materials
embolization
N-butyl cyanoacrylate
renal disease

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10.1007/s13233-021-9022-7

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@article{d5dd65d9aaf34eda9d87967039a2cba2,

title = "Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery",

abstract = "N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases. [Figure not available: see fulltext.].",

keywords = "arterial diseases, embolic materials, embolization, N-butyl cyanoacrylate, renal disease",

author = "Cho, \{Young Chul\} and Wooram Park and Kang, \{Jeon Min\} and Ryu, \{Dae Sung\} and Yubeen Park and Seo, \{Jae Won\} and Koh, \{Young Gook\} and Park, \{Jung Hoon\} and Shin, \{Ji Hoon\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Polymer Society of Korea and Springer.",

year = "2021",

month = feb,

doi = "10.1007/s13233-021-9022-7",

language = "English",

volume = "29",

pages = "178--184",

journal = "Macromolecular Research",

issn = "1598-5032",

publisher = "Polymer Society of Korea",

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}

TY - JOUR

T1 - Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization

T2 - A Preclinical Study in Rabbit Renal Artery

AU - Cho, Young Chul

AU - Park, Wooram

AU - Kang, Jeon Min

AU - Ryu, Dae Sung

AU - Park, Yubeen

AU - Seo, Jae Won

AU - Koh, Young Gook

AU - Park, Jung Hoon

AU - Shin, Ji Hoon

PY - 2021/2

Y1 - 2021/2

N2 - N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases. [Figure not available: see fulltext.].

AB - N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases. [Figure not available: see fulltext.].

KW - arterial diseases

KW - embolic materials

KW - embolization

KW - N-butyl cyanoacrylate

KW - renal disease

UR - https://www.scopus.com/pages/publications/85102072542

U2 - 10.1007/s13233-021-9022-7

DO - 10.1007/s13233-021-9022-7

M3 - Article

AN - SCOPUS:85102072542

SN - 1598-5032

VL - 29

SP - 178

EP - 184

JO - Macromolecular Research

JF - Macromolecular Research

IS - 2

ER -

Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery

Abstract

Keywords

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