New triterpenoids from the tubers of corydalis ternata: Structural elucidation and bioactivity evaluation

Two new triterpene glycosides, coryternic acid 3-O - D-glucuronopyranoside (1) and coryternic acid 3-O - D-glucuronopyranoside-6-O-methyl ester (2), were isolated from a MeOH extract of the tubers of Corydalis ternata. Acidic hydrolysis of 1 and 2 yielded a new triterpene as their aglycone, coryternic acid (3). The structures of these new compounds were determined through spectral analysis, including extensive 2D-NMR data. In this study we reported that triterpenoids were first isolated from the genus Corydalis. Compound 2 exhibited significant cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (IC15.16, 17.07, 13.32, and 11.95M, respectively) and significantly reduced NO production in lipopolysaccharide (LPS)-activated microglia/BV-2 cells with an ICvalue of 16.2M without cell toxicity.