Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

Oh Young Bang; Hyun Seok Hong; Dong Hyun Kim; Hee Kim; Jung Hyun Boo; Kyoon Huh; Inhee Mook-Jung

doi:10.1016/j.nbd.2003.12.017

Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

Oh Young Bang, Hyun Seok Hong, Dong Hyun Kim, Hee Kim, Jung Hyun Boo, Kyoon Huh, Inhee Mook-Jung

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen. In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) β-agonist, with those of estrogen. Genistein and 17β-estradiol showed comparable levels of protection against Aβ-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17β-estradiol, but not genistein, induced proliferation of uterine endometrial cells. Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease.

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Neurobiology of Disease
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.nbd.2003.12.017
State	Published - Jun 2004
Externally published	Yes

Keywords

Alzheimer's disease
Beta amyloid
Cell death
Estrogen
Estrogen receptor
Genistein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nbd.2003.12.017

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title = "Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity",

abstract = "Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen. In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) β-agonist, with those of estrogen. Genistein and 17β-estradiol showed comparable levels of protection against Aβ-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17β-estradiol, but not genistein, induced proliferation of uterine endometrial cells. Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease.",

keywords = "Alzheimer's disease, Beta amyloid, Cell death, Estrogen, Estrogen receptor, Genistein",

author = "Bang, \{Oh Young\} and Hong, \{Hyun Seok\} and Kim, \{Dong Hyun\} and Hee Kim and Boo, \{Jung Hyun\} and Kyoon Huh and Inhee Mook-Jung",

year = "2004",

month = jun,

doi = "10.1016/j.nbd.2003.12.017",

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TY - JOUR

T1 - Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

AU - Bang, Oh Young

AU - Hong, Hyun Seok

AU - Kim, Dong Hyun

AU - Kim, Hee

AU - Boo, Jung Hyun

AU - Huh, Kyoon

AU - Mook-Jung, Inhee

PY - 2004/6

Y1 - 2004/6

N2 - Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen. In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) β-agonist, with those of estrogen. Genistein and 17β-estradiol showed comparable levels of protection against Aβ-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17β-estradiol, but not genistein, induced proliferation of uterine endometrial cells. Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease.

AB - Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen. In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) β-agonist, with those of estrogen. Genistein and 17β-estradiol showed comparable levels of protection against Aβ-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17β-estradiol, but not genistein, induced proliferation of uterine endometrial cells. Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease.

KW - Alzheimer's disease

KW - Beta amyloid

KW - Cell death

KW - Estrogen

KW - Estrogen receptor

KW - Genistein

UR - https://www.scopus.com/pages/publications/2342635931

U2 - 10.1016/j.nbd.2003.12.017

DO - 10.1016/j.nbd.2003.12.017

M3 - Article

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AN - SCOPUS:2342635931

SN - 0969-9961

VL - 16

SP - 21

EP - 28

JO - Neurobiology of Disease

JF - Neurobiology of Disease

IS - 1

ER -

Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

Abstract

Keywords

UN SDGs

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