Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer

Kyueng Whan Min; Dong Hoon Kim; Sung Im Do; Seoung Wan Chae; Kyungeun Kim; Jin Hee Sohn; Jung Soo Pyo; Hyun Joo Lee; Dong Hyun Kim; Sukjoong Oh; Seon Hyeong Choi; Yong Lai Park; Chan Heun Park; Eun Kyung Kim; Mi Jung Kwon; Jinwon Seo; Kyoung Min Moon

doi:10.1007/s00428-015-1894-5

Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer

Kyueng Whan Min, Dong Hoon Kim, Sung Im Do, Seoung Wan Chae, Kyungeun Kim, Jin Hee Sohn, Jung Soo Pyo, Hyun Joo Lee, Dong Hyun Kim, Sukjoong Oh, Seon Hyeong Choi, Yong Lai Park, Chan Heun Park, Eun Kyung Kim, Mi Jung Kwon, Jinwon Seo, Kyoung Min Moon

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

GATA3 and fascin proteins are known prognostic markers in several cancers. GATA3 is a key regulator of mammary gland morphogenesis and luminal cell differentiation, whereas fascin is a pro-metastatic actin-bundling protein. In this study, we analyzed and compared the predictive abilities of GATA3 and fascin for clinical outcomes of patients with breast cancer. The combined expression pattern based on GATA3−/+ and fascin−/+ was evaluated by immunostaining using a tissue microarray, and relationships between protein expression and several clinicopathological parameters were analyzed. GATA3 expression was associated with good prognostic parameters, but fascin was correlated with poor prognostic parameters. On comparing GATA3 and fascin, we found an inverse relationship between fascin and GATA3 expressions. On analysis of combined markers, GATA3+/fascin− was correlated with improved clinical outcomes compared to GATA3−/fascin+. Univariate and multivariate analyses revealed significant differences in relapse-free and overall survival between GATA3+/fascin− and GATA3−/fascin+. Combined marker analysis of GATA3/fascin showed an inverse association and improved prognostic information for patients with breast cancer.

Original language	English
Pages (from-to)	409-416
Number of pages	8
Journal	Virchows Archiv
Volume	468
Issue number	4
DOIs	https://doi.org/10.1007/s00428-015-1894-5
State	Published - 1 Apr 2016
Externally published	Yes

Keywords

Breast cancer
Fascin protein
GATA3 protein
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00428-015-1894-5

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Min, K. W., Kim, D. H., Do, S. I., Chae, S. W., Kim, K., Sohn, J. H., Pyo, J. S., Lee, H. J., Kim, D. H., Oh, S., Choi, S. H., Park, Y. L., Park, C. H., Kim, E. K., Kwon, M. J., Seo, J., & Moon, K. M. (2016). Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer. Virchows Archiv, 468(4), 409-416. https://doi.org/10.1007/s00428-015-1894-5

@article{9b176e26391a4a628cc1548d1a16083c,

title = "Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer",

abstract = "GATA3 and fascin proteins are known prognostic markers in several cancers. GATA3 is a key regulator of mammary gland morphogenesis and luminal cell differentiation, whereas fascin is a pro-metastatic actin-bundling protein. In this study, we analyzed and compared the predictive abilities of GATA3 and fascin for clinical outcomes of patients with breast cancer. The combined expression pattern based on GATA3−/+ and fascin−/+ was evaluated by immunostaining using a tissue microarray, and relationships between protein expression and several clinicopathological parameters were analyzed. GATA3 expression was associated with good prognostic parameters, but fascin was correlated with poor prognostic parameters. On comparing GATA3 and fascin, we found an inverse relationship between fascin and GATA3 expressions. On analysis of combined markers, GATA3+/fascin− was correlated with improved clinical outcomes compared to GATA3−/fascin+. Univariate and multivariate analyses revealed significant differences in relapse-free and overall survival between GATA3+/fascin− and GATA3−/fascin+. Combined marker analysis of GATA3/fascin showed an inverse association and improved prognostic information for patients with breast cancer.",

keywords = "Breast cancer, Fascin protein, GATA3 protein, Prognosis",

author = "Min, \{Kyueng Whan\} and Kim, \{Dong Hoon\} and Do, \{Sung Im\} and Chae, \{Seoung Wan\} and Kyungeun Kim and Sohn, \{Jin Hee\} and Pyo, \{Jung Soo\} and Lee, \{Hyun Joo\} and Kim, \{Dong Hyun\} and Sukjoong Oh and Choi, \{Seon Hyeong\} and Park, \{Yong Lai\} and Park, \{Chan Heun\} and Kim, \{Eun Kyung\} and Kwon, \{Mi Jung\} and Jinwon Seo and Moon, \{Kyoung Min\}",

note = "Publisher Copyright: {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg.",

year = "2016",

month = apr,

day = "1",

doi = "10.1007/s00428-015-1894-5",

language = "English",

volume = "468",

pages = "409--416",

journal = "Virchows Archiv",

issn = "0945-6317",

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Min, KW, Kim, DH , Do, SI, Chae, SW, Kim, K, Sohn, JH, Pyo, JS, Lee, HJ, Kim, DH, Oh, S, Choi, SH, Park, YL, Park, CH, Kim, EK, Kwon, MJ, Seo, J & Moon, KM 2016, 'Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer', Virchows Archiv, vol. 468, no. 4, pp. 409-416. https://doi.org/10.1007/s00428-015-1894-5

TY - JOUR

T1 - Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer

AU - Min, Kyueng Whan

AU - Kim, Dong Hoon

AU - Do, Sung Im

AU - Chae, Seoung Wan

AU - Kim, Kyungeun

AU - Sohn, Jin Hee

AU - Pyo, Jung Soo

AU - Lee, Hyun Joo

AU - Kim, Dong Hyun

AU - Oh, Sukjoong

AU - Choi, Seon Hyeong

AU - Park, Yong Lai

AU - Park, Chan Heun

AU - Kim, Eun Kyung

AU - Kwon, Mi Jung

AU - Seo, Jinwon

AU - Moon, Kyoung Min

PY - 2016/4/1

Y1 - 2016/4/1

N2 - GATA3 and fascin proteins are known prognostic markers in several cancers. GATA3 is a key regulator of mammary gland morphogenesis and luminal cell differentiation, whereas fascin is a pro-metastatic actin-bundling protein. In this study, we analyzed and compared the predictive abilities of GATA3 and fascin for clinical outcomes of patients with breast cancer. The combined expression pattern based on GATA3−/+ and fascin−/+ was evaluated by immunostaining using a tissue microarray, and relationships between protein expression and several clinicopathological parameters were analyzed. GATA3 expression was associated with good prognostic parameters, but fascin was correlated with poor prognostic parameters. On comparing GATA3 and fascin, we found an inverse relationship between fascin and GATA3 expressions. On analysis of combined markers, GATA3+/fascin− was correlated with improved clinical outcomes compared to GATA3−/fascin+. Univariate and multivariate analyses revealed significant differences in relapse-free and overall survival between GATA3+/fascin− and GATA3−/fascin+. Combined marker analysis of GATA3/fascin showed an inverse association and improved prognostic information for patients with breast cancer.

AB - GATA3 and fascin proteins are known prognostic markers in several cancers. GATA3 is a key regulator of mammary gland morphogenesis and luminal cell differentiation, whereas fascin is a pro-metastatic actin-bundling protein. In this study, we analyzed and compared the predictive abilities of GATA3 and fascin for clinical outcomes of patients with breast cancer. The combined expression pattern based on GATA3−/+ and fascin−/+ was evaluated by immunostaining using a tissue microarray, and relationships between protein expression and several clinicopathological parameters were analyzed. GATA3 expression was associated with good prognostic parameters, but fascin was correlated with poor prognostic parameters. On comparing GATA3 and fascin, we found an inverse relationship between fascin and GATA3 expressions. On analysis of combined markers, GATA3+/fascin− was correlated with improved clinical outcomes compared to GATA3−/fascin+. Univariate and multivariate analyses revealed significant differences in relapse-free and overall survival between GATA3+/fascin− and GATA3−/fascin+. Combined marker analysis of GATA3/fascin showed an inverse association and improved prognostic information for patients with breast cancer.

KW - Breast cancer

KW - Fascin protein

KW - GATA3 protein

KW - Prognosis

UR - https://www.scopus.com/pages/publications/84952648696

U2 - 10.1007/s00428-015-1894-5

DO - 10.1007/s00428-015-1894-5

M3 - Article

C2 - 26719157

AN - SCOPUS:84952648696

SN - 0945-6317

VL - 468

SP - 409

EP - 416

JO - Virchows Archiv

JF - Virchows Archiv

IS - 4

ER -

Negative association between GATA3 and fascin could predict relapse-free and overall survival in patients with breast cancer

Abstract

Keywords

UN SDGs

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