Natural phytochemicals derived from gymnosperms in the prevention and treatment of cancers

Tayyebeh Ghaffari; Joo Hyun Hong; Solmaz Asnaashari; Safar Farajnia; Abbas Delazar; Hamed Hamishehkar; Ki Hyun Kim

doi:10.3390/ijms22126636

Natural phytochemicals derived from gymnosperms in the prevention and treatment of cancers

Tayyebeh Ghaffari, Joo Hyun Hong, Solmaz Asnaashari, Safar Farajnia, Abbas Delazar, Hamed Hamishehkar, Ki Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.

Original language	English
Article number	6636
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	12
DOIs	https://doi.org/10.3390/ijms22126636
State	Published - 2 Jun 2021

Keywords

Cancer
Gymnosperm
Natural products
Paclitaxel
Traditional medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms22126636

Cite this

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title = "Natural phytochemicals derived from gymnosperms in the prevention and treatment of cancers",

abstract = "The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.",

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AU - Ghaffari, Tayyebeh

AU - Hong, Joo Hyun

AU - Asnaashari, Solmaz

AU - Farajnia, Safar

AU - Delazar, Abbas

AU - Hamishehkar, Hamed

AU - Kim, Ki Hyun

PY - 2021/6/2

Y1 - 2021/6/2

N2 - The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.

AB - The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.

KW - Cancer

KW - Gymnosperm

KW - Natural products

KW - Paclitaxel

KW - Traditional medicine

UR - https://www.scopus.com/pages/publications/85108293911

U2 - 10.3390/ijms22126636

DO - 10.3390/ijms22126636

M3 - Review article

C2 - 34205739

AN - SCOPUS:85108293911

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JF - International Journal of Molecular Sciences

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ER -

Natural phytochemicals derived from gymnosperms in the prevention and treatment of cancers

Abstract

Keywords

UN SDGs

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