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Natural phytochemicals derived from gymnosperms in the prevention and treatment of cancers

  • Tayyebeh Ghaffari
  • , Joo Hyun Hong
  • , Solmaz Asnaashari
  • , Safar Farajnia
  • , Abbas Delazar
  • , Hamed Hamishehkar
  • , Ki Hyun Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Gymnosperms have great potential for further study for the discovery of new anticancer compounds. This review aims to provide a rational understanding and the latest developments in potential anticancer compounds derived from gymnosperms.

Original languageEnglish
Article number6636
JournalInternational Journal of Molecular Sciences
Volume22
Issue number12
DOIs
StatePublished - 2 Jun 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Cancer
  • Gymnosperm
  • Natural products
  • Paclitaxel
  • Traditional medicine

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