@inproceedings{20d388c61967433492d61ed6ca4f738c,
title = "Nanogap-based dielectric immunosensing",
abstract = "A novel device for measuring dielectric properties of protein bound to a surface without using a three-electrode system or redox couples is presented. This is achieved by reducing double layer capacitance contributions through decreased electrode gap size (60-100 nm). A proof of concept is demonstrated by immunosensing the glycoprotein laminin, which is clinically relevant to kidney disease at a concentration of 0.5 μg/ml. Dissipation factor measurements for different laminin concentrations indicate a detection limit of 10 ng/ml in a 30 microliter droplet. The measurement device described is applicable to a whole range of biological recognition systems including other protein-biomolecule binding interactions and nucleic acid hybridization.",
keywords = "Biomedical optical imaging, Biosensors, Capacitance, Dielectrics, Electrodes, Immune system, Nanobioscience, Optical sensors, Probes, Protein engineering",
author = "\{Di Carlo\}, C. and Hokwan Kang and Xianghui Zeng and Jeong, \{Ki Hun\} and Lee, \{L. P.\}",
note = "Publisher Copyright: {\textcopyright} 2003 IEEE.; 12th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2003 - Digest of Technical Papers ; Conference date: 08-06-2003 Through 12-06-2003",
year = "2003",
doi = "10.1109/SENSOR.2003.1216982",
language = "English",
series = "TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1180--1183",
booktitle = "TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers",
}
