N-Heterocyclic carbene-catalysed intermolecular Stetter reactions of acetaldehyde

Sun Min Kim; Ming Yu Jin; Mi Jin Kim; Yan Cui; Young Sug Kim; Liqiu Zhang; Choong Eui Song; Do Hyun Ryu; Jung Woon Yang

doi:10.1039/c0ob01178a

N-Heterocyclic carbene-catalysed intermolecular Stetter reactions of acetaldehyde

Sun Min Kim
, Ming Yu Jin
, Mi Jin Kim
, Yan Cui
, Young Sug Kim
, Liqiu Zhang
, Choong Eui Song
, Do Hyun Ryu
, Jung Woon Yang

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate to good enantioselectivities for the corresponding Stetter products.

Original language	English
Pages (from-to)	2069-2071
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	7
DOIs	https://doi.org/10.1039/c0ob01178a
State	Published - 7 Apr 2011

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abstract = "A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate to good enantioselectivities for the corresponding Stetter products.",

author = "Kim, \{Sun Min\} and Jin, \{Ming Yu\} and Kim, \{Mi Jin\} and Yan Cui and Kim, \{Young Sug\} and Liqiu Zhang and Song, \{Choong Eui\} and Ryu, \{Do Hyun\} and Yang, \{Jung Woon\}",

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AU - Kim, Sun Min

AU - Jin, Ming Yu

AU - Kim, Mi Jin

AU - Cui, Yan

AU - Kim, Young Sug

AU - Zhang, Liqiu

AU - Song, Choong Eui

AU - Ryu, Do Hyun

AU - Yang, Jung Woon

PY - 2011/4/7

Y1 - 2011/4/7

N2 - A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate to good enantioselectivities for the corresponding Stetter products.

AB - A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate to good enantioselectivities for the corresponding Stetter products.

UR - https://www.scopus.com/pages/publications/79952750874

U2 - 10.1039/c0ob01178a

DO - 10.1039/c0ob01178a

M3 - Article

AN - SCOPUS:79952750874

SN - 1477-0520

VL - 9

SP - 2069

EP - 2071

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

N-Heterocyclic carbene-catalysed intermolecular Stetter reactions of acetaldehyde

Abstract

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