MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression

Taewan Kim; Ri Cui; Young Jun Jeon; Paolo Fadda; Hansjuerg Alder; Carlo M. Croce

doi:10.18632/oncotarget.3909

MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression

Taewan Kim
, Ri Cui
, Young Jun Jeon
, Paolo Fadda
, Hansjuerg Alder
, Carlo M. Croce

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The transcription factor MYC is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. The recent identification of MYC-regulated long noncoding RNAs (lncRNAs) expands our knowledge of the role of lncRNAs in MYC functions. Here, we identify MYC-repressed lncRNAs named MYCLo-4, -5 and -6 by comparing 3 categories of lncRNAs (downregulated in highly MYC-expressing colorectal cancer, up-regulated by MYC knockdown in HCT116, upregulated by MYC knockdown in RKO). The MYC-repressed MYCLos are implicated in MYC-modulated cell proliferation through cell cycle regulation. By screening cell cycle-related genes regulated by MYC and the MYC-repressed MYCLos, we identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6.

Original language	English
Pages (from-to)	18780-18789
Number of pages	10
Journal	Oncotarget
Volume	6
Issue number	22
DOIs	https://doi.org/10.18632/oncotarget.3909
State	Published - 2015
Externally published	Yes

Keywords

Cell cycle
Cell proliferation
Long noncoding RNA
MYC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.3909

Cite this

@article{514e522f11a746bb99f82a9829ecde6a,

title = "MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression",

abstract = "The transcription factor MYC is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. The recent identification of MYC-regulated long noncoding RNAs (lncRNAs) expands our knowledge of the role of lncRNAs in MYC functions. Here, we identify MYC-repressed lncRNAs named MYCLo-4, -5 and -6 by comparing 3 categories of lncRNAs (downregulated in highly MYC-expressing colorectal cancer, up-regulated by MYC knockdown in HCT116, upregulated by MYC knockdown in RKO). The MYC-repressed MYCLos are implicated in MYC-modulated cell proliferation through cell cycle regulation. By screening cell cycle-related genes regulated by MYC and the MYC-repressed MYCLos, we identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6.",

keywords = "Cell cycle, Cell proliferation, Long noncoding RNA, MYC",

author = "Taewan Kim and Ri Cui and Jeon, \{Young Jun\} and Paolo Fadda and Hansjuerg Alder and Croce, \{Carlo M.\}",

year = "2015",

doi = "10.18632/oncotarget.3909",

language = "English",

volume = "6",

pages = "18780--18789",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals LLC",

number = "22",

}

TY - JOUR

T1 - MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression

AU - Kim, Taewan

AU - Cui, Ri

AU - Jeon, Young Jun

AU - Fadda, Paolo

AU - Alder, Hansjuerg

AU - Croce, Carlo M.

PY - 2015

Y1 - 2015

N2 - The transcription factor MYC is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. The recent identification of MYC-regulated long noncoding RNAs (lncRNAs) expands our knowledge of the role of lncRNAs in MYC functions. Here, we identify MYC-repressed lncRNAs named MYCLo-4, -5 and -6 by comparing 3 categories of lncRNAs (downregulated in highly MYC-expressing colorectal cancer, up-regulated by MYC knockdown in HCT116, upregulated by MYC knockdown in RKO). The MYC-repressed MYCLos are implicated in MYC-modulated cell proliferation through cell cycle regulation. By screening cell cycle-related genes regulated by MYC and the MYC-repressed MYCLos, we identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6.

AB - The transcription factor MYC is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. The recent identification of MYC-regulated long noncoding RNAs (lncRNAs) expands our knowledge of the role of lncRNAs in MYC functions. Here, we identify MYC-repressed lncRNAs named MYCLo-4, -5 and -6 by comparing 3 categories of lncRNAs (downregulated in highly MYC-expressing colorectal cancer, up-regulated by MYC knockdown in HCT116, upregulated by MYC knockdown in RKO). The MYC-repressed MYCLos are implicated in MYC-modulated cell proliferation through cell cycle regulation. By screening cell cycle-related genes regulated by MYC and the MYC-repressed MYCLos, we identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6.

KW - Cell cycle

KW - Cell proliferation

KW - Long noncoding RNA

KW - MYC

UR - https://www.scopus.com/pages/publications/84938847446

U2 - 10.18632/oncotarget.3909

DO - 10.18632/oncotarget.3909

M3 - Article

C2 - 26003165

AN - SCOPUS:84938847446

SN - 1949-2553

VL - 6

SP - 18780

EP - 18789

JO - Oncotarget

JF - Oncotarget

IS - 22

ER -

MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression

Abstract

Keywords

UN SDGs

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