TY - JOUR
T1 - Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
AU - The Cancer Genome Atlas Research Network
AU - Hoadley, Katherine A.
AU - Yau, Christina
AU - Wolf, Denise M.
AU - Cherniack, Andrew D.
AU - Tamborero, David
AU - Ng, Sam
AU - Leiserson, Max D.M.
AU - Niu, Beifang
AU - McLellan, Michael D.
AU - Uzunangelov, Vladislav
AU - Zhang, Jiashan
AU - Kandoth, Cyriac
AU - Akbani, Rehan
AU - Shen, Hui
AU - Omberg, Larsson
AU - Chu, Andy
AU - Margolin, Adam A.
AU - Van't Veer, Laura J.
AU - Lopez-Bigas, Nuria
AU - Laird, Peter W.
AU - Raphael, Benjamin J.
AU - Ding, Li
AU - Robertson, A. Gordon
AU - Byers, Lauren A.
AU - Mills, Gordon B.
AU - Weinstein, John N.
AU - Van Waes, Carter
AU - Chen, Zhong
AU - Collisson, Eric A.
AU - Benz, Christopher C.
AU - Perou, Charles M.
AU - Stuart, Joshua M.
AU - Abbott, Rachel
AU - Abbott, Scott
AU - Aksoy, B. Arman
AU - Aldape, Kenneth
AU - Ally, Adrian
AU - Amin, Samirkumar
AU - Anastassiou, Dimitris
AU - Auman, J. Todd
AU - Baggerly, Keith A.
AU - Balasundaram, Miruna
AU - Balu, Saianand
AU - Baylin, Stephen B.
AU - Benz, Stephen C.
AU - Berman, Benjamin P.
AU - Bernard, Brady
AU - Bhatt, Ami S.
AU - Birol, Inanc
AU - Kim, Hoon
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/8/14
Y1 - 2014/8/14
N2 - Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-oforigin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pancancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.
AB - Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-oforigin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pancancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.
UR - https://www.scopus.com/pages/publications/84908460595
U2 - 10.1016/j.cell.2014.06.049
DO - 10.1016/j.cell.2014.06.049
M3 - Article
C2 - 25109877
AN - SCOPUS:84908460595
SN - 0092-8674
VL - 158
SP - 929
EP - 944
JO - Cell
JF - Cell
IS - 4
ER -
SDG 3 Good Health and Well-being