Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery

  • Jaeyun Kim
  • , Hoe Suk Kim
  • , Nohyun Lee
  • , Taeho Kim
  • , Hyoungsu Kim
  • , Taekyung Yu
  • , In Chan Song
  • , Woo Kyung Moon
  • , Taeghwan Hyeon

Research output: Contribution to journalArticlepeer-review

1226 Scopus citations

Abstract

Magnetic, fluorescent core-shell nanoparticles consist of a single Fe 3O4 nanocrystal core and a dye-doped mesoporous silica shell with a poly(ethylene glycol) coating (see picture of TEM images and schematic depictions). These nanoparticles can be used as magnetic resonance and fluorescence imaging agents, and as drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis and therapy. (Figure Presented)

Original languageEnglish
Pages (from-to)8438-8441
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number44
DOIs
StatePublished - 20 Oct 2008
Externally publishedYes

Keywords

  • Drug delivery
  • Fluorescence
  • Magnetic resonance
  • Mesoporous materials
  • Nanostructures

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