Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy

Dong Jin Lee; Ga Young Park; Kyung Taek Oh; Nam Muk Oh; Dong Sup Kwag; Yu Seok Youn; Young Taik Oh; Jin Woo Park; Eun Seong Lee

doi:10.1016/j.ijpharm.2012.05.068

Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy

Dong Jin Lee
, Ga Young Park
, Kyung Taek Oh
, Nam Muk Oh
, Dong Sup Kwag
, Yu Seok Youn
, Young Taik Oh
, Jin Woo Park
, Eun Seong Lee

Department of Pharmacy

The Catholic University of Korea
Chung-Ang University
Yonsei University
Amorepacific Corporation

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe₃O₄ were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W₁/O/W ₂ (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe₃O₄ allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex® (commercial contrast agent).

Original language	English
Pages (from-to)	257-263
Number of pages	7
Journal	International Journal of Pharmaceutics
Volume	434
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2012.05.068
State	Published - 15 Sep 2012

Keywords

FeO
Magnetic resonance imaging (MRI)
Photodynamic therapy (PDT)
Poly (lactide-co-glycolide)

Access to Document

10.1016/j.ijpharm.2012.05.068

Cite this

@article{cbd4cbff537b4cdb88c9133def5ac764,

title = "Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy",

abstract = "Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe3O4 were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W1/O/W 2 (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe3O4 allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex{\textregistered} (commercial contrast agent).",

keywords = "FeO, Magnetic resonance imaging (MRI), Photodynamic therapy (PDT), Poly (lactide-co-glycolide)",

author = "Lee, \{Dong Jin\} and Park, \{Ga Young\} and Oh, \{Kyung Taek\} and Oh, \{Nam Muk\} and Kwag, \{Dong Sup\} and Youn, \{Yu Seok\} and Oh, \{Young Taik\} and Park, \{Jin Woo\} and Lee, \{Eun Seong\}",

year = "2012",

month = sep,

day = "15",

doi = "10.1016/j.ijpharm.2012.05.068",

language = "English",

volume = "434",

pages = "257--263",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy

AU - Lee, Dong Jin

AU - Park, Ga Young

AU - Oh, Kyung Taek

AU - Oh, Nam Muk

AU - Kwag, Dong Sup

AU - Youn, Yu Seok

AU - Oh, Young Taik

AU - Park, Jin Woo

AU - Lee, Eun Seong

PY - 2012/9/15

Y1 - 2012/9/15

N2 - Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe3O4 were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W1/O/W 2 (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe3O4 allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex® (commercial contrast agent).

AB - Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe3O4 were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W1/O/W 2 (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe3O4 allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex® (commercial contrast agent).

KW - FeO

KW - Magnetic resonance imaging (MRI)

KW - Photodynamic therapy (PDT)

KW - Poly (lactide-co-glycolide)

UR - https://www.scopus.com/pages/publications/84864143008

U2 - 10.1016/j.ijpharm.2012.05.068

DO - 10.1016/j.ijpharm.2012.05.068

M3 - Article

C2 - 22664459

AN - SCOPUS:84864143008

SN - 0378-5173

VL - 434

SP - 257

EP - 263

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this