Multifunctional hybrid nanoconjugates for efficient in vivo delivery of immunomodulating oligonucleotides and enhanced antitumor immunity

Ji Hyun Kim; Young Woock Noh; Min Beom Heo; Mi Young Cho; Yong Taik Lim

doi:10.1002/anie.201204989

Multifunctional hybrid nanoconjugates for efficient in vivo delivery of immunomodulating oligonucleotides and enhanced antitumor immunity

Ji Hyun Kim, Young Woock Noh, Min Beom Heo, Mi Young Cho, Yong Taik Lim

Chungnam National University

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to synergistically enhance the antitumor immune response in dendritic cells and in tumor-bearing mice.

Original language	English
Pages (from-to)	9670-9673
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	38
DOIs	https://doi.org/10.1002/anie.201204989
State	Published - 17 Sep 2012
Externally published	Yes

Keywords

antitumor agents
dendritic cells
drug delivery
fluorescent probes
hybrid nanoconjugates

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201204989

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title = "Multifunctional hybrid nanoconjugates for efficient in vivo delivery of immunomodulating oligonucleotides and enhanced antitumor immunity",

abstract = "A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to synergistically enhance the antitumor immune response in dendritic cells and in tumor-bearing mice.",

keywords = "antitumor agents, dendritic cells, drug delivery, fluorescent probes, hybrid nanoconjugates",

author = "Kim, \{Ji Hyun\} and Noh, \{Young Woock\} and Heo, \{Min Beom\} and Cho, \{Mi Young\} and Lim, \{Yong Taik\}",

year = "2012",

month = sep,

day = "17",

doi = "10.1002/anie.201204989",

language = "English",

volume = "51",

pages = "9670--9673",

journal = "Angewandte Chemie - International Edition",

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T1 - Multifunctional hybrid nanoconjugates for efficient in vivo delivery of immunomodulating oligonucleotides and enhanced antitumor immunity

AU - Kim, Ji Hyun

AU - Noh, Young Woock

AU - Heo, Min Beom

AU - Cho, Mi Young

AU - Lim, Yong Taik

PY - 2012/9/17

Y1 - 2012/9/17

N2 - A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to synergistically enhance the antitumor immune response in dendritic cells and in tumor-bearing mice.

AB - A winning combination: Multifunctional hybrid nanoconjugates (HNCs) based on polymer nanoparticles containing quantum dots (QDs) conjugated with CpG oligonucleotides (as a ligand for TLR9) and STAT3 siRNAs (to suppress the immune response) have been synthesized (see scheme). These HNCs were shown to synergistically enhance the antitumor immune response in dendritic cells and in tumor-bearing mice.

KW - antitumor agents

KW - dendritic cells

KW - drug delivery

KW - fluorescent probes

KW - hybrid nanoconjugates

UR - https://www.scopus.com/pages/publications/84866419788

U2 - 10.1002/anie.201204989

DO - 10.1002/anie.201204989

M3 - Article

C2 - 22915476

AN - SCOPUS:84866419788

SN - 1433-7851

VL - 51

SP - 9670

EP - 9673

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 38

ER -

Multifunctional hybrid nanoconjugates for efficient in vivo delivery of immunomodulating oligonucleotides and enhanced antitumor immunity

Abstract

Keywords

UN SDGs

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