mRNA-Producing Pseudo-nucleus System

Seung Won Shin; Kyung Soo Park; Woo Jung Shin; Soong Ho Um

doi:10.1002/smll.201501334

mRNA-Producing Pseudo-nucleus System

Seung Won Shin, Kyung Soo Park, Woo Jung Shin, Soong Ho Um

Department of Chemical Engineering

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A pseudo-eukaryotic nucleus (PEN) system consisting of a gene-containing DNA hydrogel encapsulated in a liposome is fabricated. Owing to the structural characteristics of gene-containing DNA hydrogel, mRNA transcription efficiency is promoted 2.57-fold. Through the use of PEN as a platform for mRNA delivery to the cytosol, prolonged protein translation is achieved.

Original language	English
Pages (from-to)	5515-5519
Number of pages	5
Journal	Small
Volume	11
Issue number	41
DOIs	https://doi.org/10.1002/smll.201501334
State	Published - 1 Nov 2015

Keywords

artificial cell nucleus
biomimicry
DNA nanotechnology
messenger RNA expression
nucleus mimicry

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10.1002/smll.201501334

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title = "mRNA-Producing Pseudo-nucleus System",

abstract = "A pseudo-eukaryotic nucleus (PEN) system consisting of a gene-containing DNA hydrogel encapsulated in a liposome is fabricated. Owing to the structural characteristics of gene-containing DNA hydrogel, mRNA transcription efficiency is promoted 2.57-fold. Through the use of PEN as a platform for mRNA delivery to the cytosol, prolonged protein translation is achieved.",

keywords = "artificial cell nucleus, biomimicry, DNA nanotechnology, messenger RNA expression, nucleus mimicry",

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AU - Shin, Seung Won

AU - Park, Kyung Soo

AU - Shin, Woo Jung

AU - Um, Soong Ho

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AB - A pseudo-eukaryotic nucleus (PEN) system consisting of a gene-containing DNA hydrogel encapsulated in a liposome is fabricated. Owing to the structural characteristics of gene-containing DNA hydrogel, mRNA transcription efficiency is promoted 2.57-fold. Through the use of PEN as a platform for mRNA delivery to the cytosol, prolonged protein translation is achieved.

KW - artificial cell nucleus

KW - biomimicry

KW - DNA nanotechnology

KW - messenger RNA expression

KW - nucleus mimicry

UR - https://www.scopus.com/pages/publications/84946481687

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mRNA-Producing Pseudo-nucleus System

Abstract

Keywords

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