Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures

Jin Woong Lee; Byoungsang Lee; Cheol Hyun Park; Jun Hyuk Heo; Tae Yoon Lee; Dongtak Lee; Jina Bae; Priyannth Ramasami Sundharbaabu; Won Kyun Yeom; Sudong Chae; Jae Hyuk Lim; Seok Won Lee; Jin Seok Choi; Hyung Bin Bae; Jae Young Choi; Eun Ho Lee; Dae Sung Yoon; Geun Young Yeom; Hyunjung Shin; Jung Heon Lee

doi:10.1002/adma.202406179

Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures

Jin Woong Lee
, Byoungsang Lee
, Cheol Hyun Park
, Jun Hyuk Heo
, Tae Yoon Lee
, Dongtak Lee
, Jina Bae
, Priyannth Ramasami Sundharbaabu
, Won Kyun Yeom
, Sudong Chae
, Jae Hyuk Lim
, Seok Won Lee
, Jin Seok Choi
, Hyung Bin Bae
, Jae Young Choi
, Eun Ho Lee
, Dae Sung Yoon
, Geun Young Yeom
, Hyunjung Shin
, Jung Heon Lee

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA₁Ca_2.2(PO₄)_1.3OH_2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.

Original language	English
Article number	2406179
Journal	Advanced Materials
Volume	36
Issue number	41
DOIs	https://doi.org/10.1002/adma.202406179
State	Published - 10 Oct 2024

Keywords

DNA
DNApatite
bone mimicking structure
elastic apatite
organo–inorganic structure
sub-nanometer nacre mimetic architecture

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10.1002/adma.202406179

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Lee, J. W., Lee, B., Park, C. H., Heo, J. H., Lee, T. Y., Lee, D., Bae, J., Sundharbaabu, P. R., Yeom, W. K., Chae, S., Lim, J. H., Lee, S. W., Choi, J. S., Bae, H. B., Choi, J. Y., Lee, E. H., Yoon, D. S., Yeom, G. Y., Shin, H., & Lee, J. H. (2024). Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures. Advanced Materials, 36(41), Article 2406179. https://doi.org/10.1002/adma.202406179

@article{7922eacef8ce45e48860e57fd08245ac,

title = "Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures",

abstract = "Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA1Ca2.2(PO4)1.3OH2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.",

keywords = "DNA, DNApatite, bone mimicking structure, elastic apatite, organo–inorganic structure, sub-nanometer nacre mimetic architecture",

author = "Lee, \{Jin Woong\} and Byoungsang Lee and Park, \{Cheol Hyun\} and Heo, \{Jun Hyuk\} and Lee, \{Tae Yoon\} and Dongtak Lee and Jina Bae and Sundharbaabu, \{Priyannth Ramasami\} and Yeom, \{Won Kyun\} and Sudong Chae and Lim, \{Jae Hyuk\} and Lee, \{Seok Won\} and Choi, \{Jin Seok\} and Bae, \{Hyung Bin\} and Choi, \{Jae Young\} and Lee, \{Eun Ho\} and Yoon, \{Dae Sung\} and Yeom, \{Geun Young\} and Hyunjung Shin and Lee, \{Jung Heon\}",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley-VCH GmbH.",

year = "2024",

month = oct,

day = "10",

doi = "10.1002/adma.202406179",

language = "English",

volume = "36",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

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}

Lee, JW, Lee, B, Park, CH, Heo, JH, Lee, TY, Lee, D, Bae, J, Sundharbaabu, PR, Yeom, WK, Chae, S, Lim, JH, Lee, SW, Choi, JS, Bae, HB, Choi, JY , Lee, EH, Yoon, DS, Yeom, GY , Shin, H & Lee, JH 2024, 'Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures', Advanced Materials, vol. 36, no. 41, 2406179. https://doi.org/10.1002/adma.202406179

TY - JOUR

T1 - Monolithic DNApatite

T2 - An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures

AU - Lee, Jin Woong

AU - Lee, Byoungsang

AU - Park, Cheol Hyun

AU - Heo, Jun Hyuk

AU - Lee, Tae Yoon

AU - Lee, Dongtak

AU - Bae, Jina

AU - Sundharbaabu, Priyannth Ramasami

AU - Yeom, Won Kyun

AU - Chae, Sudong

AU - Lim, Jae Hyuk

AU - Lee, Seok Won

AU - Choi, Jin Seok

AU - Bae, Hyung Bin

AU - Choi, Jae Young

AU - Lee, Eun Ho

AU - Yoon, Dae Sung

AU - Yeom, Geun Young

AU - Shin, Hyunjung

AU - Lee, Jung Heon

PY - 2024/10/10

Y1 - 2024/10/10

N2 - Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA1Ca2.2(PO4)1.3OH2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.

AB - Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA1Ca2.2(PO4)1.3OH2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.

KW - DNA

KW - DNApatite

KW - bone mimicking structure

KW - elastic apatite

KW - organo–inorganic structure

KW - sub-nanometer nacre mimetic architecture

UR - https://www.scopus.com/pages/publications/85198378928

U2 - 10.1002/adma.202406179

DO - 10.1002/adma.202406179

M3 - Article

C2 - 39003621

AN - SCOPUS:85198378928

SN - 0935-9648

VL - 36

JO - Advanced Materials

JF - Advanced Materials

IS - 41

M1 - 2406179

ER -

Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures

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Keywords

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