Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

Parmeswaran Diagaradjane; Anil Shetty; James C. Wang; Andrew M. Elliott; Jon Schwartz; Shujun Shentu; Hee C. Park; Amit Deorukhkar; R. Jason Stafford; Sang H. Cho; James W. Tunnell; John D. Hazle; Sunil Krishnan

doi:10.1021/nl080496z

Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

Parmeswaran Diagaradjane, Anil Shetty, James C. Wang, Andrew M. Elliott, Jon Schwartz, Shujun Shentu, Hee C. Park, Amit Deorukhkar, R. Jason Stafford, Sang H. Cho, James W. Tunnell, John D. Hazle, Sunil Krishnan

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.

Original language	English
Pages (from-to)	1492-1500
Number of pages	9
Journal	Nano Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.1021/nl080496z
State	Published - May 2008
Externally published	Yes

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Diagaradjane, P., Shetty, A., Wang, J. C., Elliott, A. M., Schwartz, J., Shentu, S., Park, H. C., Deorukhkar, A., Stafford, R. J., Cho, S. H., Tunnell, J. W., Hazle, J. D., & Krishnan, S. (2008). Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. Nano Letters, 8(5), 1492-1500. https://doi.org/10.1021/nl080496z

@article{af495ef5826d4803a1c9a499c54dfb4c,

title = "Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy",

abstract = "We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.",

author = "Parmeswaran Diagaradjane and Anil Shetty and Wang, \{James C.\} and Elliott, \{Andrew M.\} and Jon Schwartz and Shujun Shentu and Park, \{Hee C.\} and Amit Deorukhkar and Stafford, \{R. Jason\} and Cho, \{Sang H.\} and Tunnell, \{James W.\} and Hazle, \{John D.\} and Sunil Krishnan",

year = "2008",

month = may,

doi = "10.1021/nl080496z",

language = "English",

volume = "8",

pages = "1492--1500",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "5",

}

Diagaradjane, P, Shetty, A, Wang, JC, Elliott, AM, Schwartz, J, Shentu, S, Park, HC, Deorukhkar, A, Stafford, RJ, Cho, SH, Tunnell, JW, Hazle, JD & Krishnan, S 2008, 'Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy', Nano Letters, vol. 8, no. 5, pp. 1492-1500. https://doi.org/10.1021/nl080496z

Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. / Diagaradjane, Parmeswaran; Shetty, Anil; Wang, James C. et al.
In: Nano Letters, Vol. 8, No. 5, 05.2008, p. 1492-1500.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia

T2 - Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

AU - Diagaradjane, Parmeswaran

AU - Shetty, Anil

AU - Wang, James C.

AU - Elliott, Andrew M.

AU - Schwartz, Jon

AU - Shentu, Shujun

AU - Park, Hee C.

AU - Deorukhkar, Amit

AU - Stafford, R. Jason

AU - Cho, Sang H.

AU - Tunnell, James W.

AU - Hazle, John D.

AU - Krishnan, Sunil

PY - 2008/5

Y1 - 2008/5

N2 - We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.

AB - We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.

UR - https://www.scopus.com/pages/publications/46749146194

U2 - 10.1021/nl080496z

DO - 10.1021/nl080496z

M3 - Article

C2 - 18412402

AN - SCOPUS:46749146194

SN - 1530-6984

VL - 8

SP - 1492

EP - 1500

JO - Nano Letters

JF - Nano Letters

IS - 5

ER -

Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

Abstract

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