Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

Sung Hoon Baik; Moon Yong Cha; Young Min Hyun; Hansang Cho; Bashar Hamza; Dong Kyu Kim; Sun Ho Han; Heesun Choi; Kyung Ho Kim; Minho Moon; Jeewoo Lee; Minsoo Kim; Daniel Irimia; Inhee Mook-Jung

doi:10.1016/j.neurobiolaging.2014.01.003

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

Sung Hoon Baik
, Moon Yong Cha
, Young Min Hyun
, Hansang Cho
, Bashar Hamza
, Dong Kyu Kim
, Sun Ho Han
, Heesun Choi
, Kyung Ho Kim
, Minho Moon
, Jeewoo Lee
, Minsoo Kim
, Daniel Irimia
, Inhee Mook-Jung

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.

Original language	English
Pages (from-to)	1286-1292
Number of pages	7
Journal	Neurobiology of Aging
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.01.003
State	Published - Jun 2014
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid plaques
Immune cells
Neutrophils

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10.1016/j.neurobiolaging.2014.01.003

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title = "Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model",

abstract = "Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.",

keywords = "Alzheimer's disease, Amyloid plaques, Immune cells, Neutrophils",

author = "Baik, \{Sung Hoon\} and Cha, \{Moon Yong\} and Hyun, \{Young Min\} and Hansang Cho and Bashar Hamza and Kim, \{Dong Kyu\} and Han, \{Sun Ho\} and Heesun Choi and Kim, \{Kyung Ho\} and Minho Moon and Jeewoo Lee and Minsoo Kim and Daniel Irimia and Inhee Mook-Jung",

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doi = "10.1016/j.neurobiolaging.2014.01.003",

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T1 - Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

AU - Baik, Sung Hoon

AU - Cha, Moon Yong

AU - Hyun, Young Min

AU - Cho, Hansang

AU - Hamza, Bashar

AU - Kim, Dong Kyu

AU - Han, Sun Ho

AU - Choi, Heesun

AU - Kim, Kyung Ho

AU - Moon, Minho

AU - Lee, Jeewoo

AU - Kim, Minsoo

AU - Irimia, Daniel

AU - Mook-Jung, Inhee

PY - 2014/6

Y1 - 2014/6

N2 - Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.

AB - Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.

KW - Alzheimer's disease

KW - Amyloid plaques

KW - Immune cells

KW - Neutrophils

UR - https://www.scopus.com/pages/publications/84903372586

U2 - 10.1016/j.neurobiolaging.2014.01.003

DO - 10.1016/j.neurobiolaging.2014.01.003

M3 - Article

C2 - 24485508

AN - SCOPUS:84903372586

SN - 0197-4580

VL - 35

SP - 1286

EP - 1292

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 6

ER -

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

Abstract

Keywords

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