Microsatellite marker in gamma-aminobutyric acid-A receptor beta 3 subunit gene and autism spectrum disorders in Korean trios

Hanik K. Yoo; Seockhoon Chung; Jin Pyo Hong; Boong Nyun Kim; Soo Churl Cho

doi:10.3349/ymj.2009.50.2.304

Microsatellite marker in gamma-aminobutyric acid-A receptor beta 3 subunit gene and autism spectrum disorders in Korean trios

Hanik K. Yoo
, Seockhoon Chung
, Jin Pyo Hong
, Boong Nyun Kim
, Soo Churl Cho

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 ± 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.

Original language	English
Pages (from-to)	304-306
Number of pages	3
Journal	Yonsei Medical Journal
Volume	50
Issue number	2
DOIs	https://doi.org/10.3349/ymj.2009.50.2.304
State	Published - 2009
Externally published	Yes

Keywords

Autism spectrum disorders
Gamma-aminobutyric acid-A receptor subunit β3
Genetics
Microsatellite
Transmission disequilibrium test

Access to Document

10.3349/ymj.2009.50.2.304

Cite this

@article{900c589a45d0463c915aefe1a8204c52,

title = "Microsatellite marker in gamma-aminobutyric acid-A receptor beta 3 subunit gene and autism spectrum disorders in Korean trios",

abstract = "This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0\%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6\%), 33.6 ± 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.",

keywords = "Autism spectrum disorders, Gamma-aminobutyric acid-A receptor subunit β3, Genetics, Microsatellite, Transmission disequilibrium test",

author = "Yoo, \{Hanik K.\} and Seockhoon Chung and Hong, \{Jin Pyo\} and Kim, \{Boong Nyun\} and Cho, \{Soo Churl\}",

year = "2009",

doi = "10.3349/ymj.2009.50.2.304",

language = "English",

volume = "50",

pages = "304--306",

journal = "Yonsei Medical Journal",

issn = "0513-5796",

publisher = "Yonsei University College of Medicine",

number = "2",

}

TY - JOUR

T1 - Microsatellite marker in gamma-aminobutyric acid-A receptor beta 3 subunit gene and autism spectrum disorders in Korean trios

AU - Yoo, Hanik K.

AU - Chung, Seockhoon

AU - Hong, Jin Pyo

AU - Kim, Boong Nyun

AU - Cho, Soo Churl

PY - 2009

Y1 - 2009

N2 - This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 ± 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.

AB - This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 ± 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.

KW - Autism spectrum disorders

KW - Gamma-aminobutyric acid-A receptor subunit β3

KW - Genetics

KW - Microsatellite

KW - Transmission disequilibrium test

UR - https://www.scopus.com/pages/publications/66549100493

U2 - 10.3349/ymj.2009.50.2.304

DO - 10.3349/ymj.2009.50.2.304

M3 - Article

C2 - 19430570

AN - SCOPUS:66549100493

SN - 0513-5796

VL - 50

SP - 304

EP - 306

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

IS - 2

ER -

Microsatellite marker in gamma-aminobutyric acid-A receptor beta 3 subunit gene and autism spectrum disorders in Korean trios

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this