TY - JOUR
T1 - Metabolic dysfunction-associated fatty liver disease and heavy alcohol consumption increase mortality:A nationwide study
AU - Cho, So Hyun
AU - Kim, Seohyun
AU - Oh, Rosa
AU - Kim, Ji Yoon
AU - Lee, You Bin
AU - Jin, Sang Man
AU - Hur, Kyu Yeon
AU - Kim, Gyuri
AU - Kim, Jae Hyeon
N1 - Publisher Copyright:
© Asian Pacific Association for the Study of the Liver 2024.
PY - 2024/8
Y1 - 2024/8
N2 - Background: The effects of excessive alcohol consumption on the prognosis of metabolic dysfunction-associated fatty liver disease (MAFLD) remain unclear. We investigated all-cause and cause-specific mortality according to the amount of alcohol consumed by Asian individuals with MAFLD. Methods: This nationwide retrospective study included 996,508 adults aged 40–79 years who underwent health check-ups between 2009 and 2012. Participants were categorized by the alcohol consumption–non-alcohol, moderate alcohol, and heavy alcohol group (≥ 30 g/day for men, ≥ 20 g/day for women) and by the combination of the presence or absence of MAFLD. Hepatic steatosis was defined as the fatty liver index ≥ 30. Cox analyses were used to analyze the association between alcohol consumption and MAFLD and all-cause and cause-specific mortality. Results: MAFLD significantly increased all-cause, liver-, and cancer-related mortality. Individuals with both MAFLD and heavy alcohol consumption expressed the highest mortality risk in liver-related mortality compared to non-MAFLD and non-alcohol group (adjusted hazard ratio (HR), 9.8; 95% confidence interval (CI), 8.20–12.29). Regardless of MAFLD, heavy alcohol consumption increased the risk of liver- and cancer-related mortality. Conclusions: MAFLD and heavy alcohol consumption increased all-cause, liver-, and cancer-related mortality. Heavy alcohol consumption and MAFLD synergistically increase liver-related mortality.
AB - Background: The effects of excessive alcohol consumption on the prognosis of metabolic dysfunction-associated fatty liver disease (MAFLD) remain unclear. We investigated all-cause and cause-specific mortality according to the amount of alcohol consumed by Asian individuals with MAFLD. Methods: This nationwide retrospective study included 996,508 adults aged 40–79 years who underwent health check-ups between 2009 and 2012. Participants were categorized by the alcohol consumption–non-alcohol, moderate alcohol, and heavy alcohol group (≥ 30 g/day for men, ≥ 20 g/day for women) and by the combination of the presence or absence of MAFLD. Hepatic steatosis was defined as the fatty liver index ≥ 30. Cox analyses were used to analyze the association between alcohol consumption and MAFLD and all-cause and cause-specific mortality. Results: MAFLD significantly increased all-cause, liver-, and cancer-related mortality. Individuals with both MAFLD and heavy alcohol consumption expressed the highest mortality risk in liver-related mortality compared to non-MAFLD and non-alcohol group (adjusted hazard ratio (HR), 9.8; 95% confidence interval (CI), 8.20–12.29). Regardless of MAFLD, heavy alcohol consumption increased the risk of liver- and cancer-related mortality. Conclusions: MAFLD and heavy alcohol consumption increased all-cause, liver-, and cancer-related mortality. Heavy alcohol consumption and MAFLD synergistically increase liver-related mortality.
KW - Alcohol consumption
KW - All-cause mortality
KW - Cause-specific mortality
KW - Metabolic dysfunction-associated fatty liver disease
UR - https://www.scopus.com/pages/publications/85194585671
U2 - 10.1007/s12072-024-10671-9
DO - 10.1007/s12072-024-10671-9
M3 - Article
C2 - 38806774
AN - SCOPUS:85194585671
SN - 1936-0533
VL - 18
SP - 1168
EP - 1177
JO - Hepatology International
JF - Hepatology International
IS - 4
ER -
