Abstract
Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures had a higher cellular retention in comparison to pH-insensitive, control AuNPs (cAuNPs), which is important for the cell-based delivery process. PSAuNP-laden MSCs (MSC-PSAuNPs) injected intravenously to tumor-bearing mice show a 37-fold higher tumor-targeting efficiency (5.6% of the injected dose) and 8.3°C higher heat generation compared to injections of cAuNPs after irradiation, which results in a significantly enhanced anticancer effect.
| Original language | English |
|---|---|
| Pages (from-to) | 9678-9690 |
| Number of pages | 13 |
| Journal | ACS Nano |
| Volume | 9 |
| Issue number | 10 |
| DOIs | |
| State | Published - 27 Oct 2015 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- gold nanoparticles
- mesenchymal stem cells
- pH-sensitive
- photothermal therapy
- tumor tropism
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