Mesenchymal stem cell therapy for intractable neonatal disorders

So Yoon Ahn; Won Soon Park; Se In Sung; Yun Sil Chang

doi:10.1016/j.pedneo.2020.11.007

Mesenchymal stem cell therapy for intractable neonatal disorders

Department of Pediatrics

Sungkyunkwan University

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Mesenchymal stem cell (MSC) transplantation has emerged as a new promising therapeutic strategy for the treatment of intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and hypoxic-ischemic encephalopathy (HIE). In response to inflammatory and noxious environments, MSCs secrete various paracrine factors that perform several reparative functions, including exerting anti-inflammatory, anti-oxidative, anti-apoptotic, and anti-fibrotic effects, to enhance the regeneration of damaged cells and tissues. In this review, we summarize recent advances in stem cell research focusing on the use of MSCs in the prevention and treatment of newborn BPD, IVH and HIE, with particular emphasis on preclinical and clinical data.

Original language	English
Pages (from-to)	S16-S21
Journal	Pediatrics and Neonatology
Volume	62
DOIs	https://doi.org/10.1016/j.pedneo.2020.11.007
State	Published - Feb 2021

Keywords

clinical trial
infant, newborn
stem cell transplantation
stem cells

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10.1016/j.pedneo.2020.11.007

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title = "Mesenchymal stem cell therapy for intractable neonatal disorders",

abstract = "Mesenchymal stem cell (MSC) transplantation has emerged as a new promising therapeutic strategy for the treatment of intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and hypoxic-ischemic encephalopathy (HIE). In response to inflammatory and noxious environments, MSCs secrete various paracrine factors that perform several reparative functions, including exerting anti-inflammatory, anti-oxidative, anti-apoptotic, and anti-fibrotic effects, to enhance the regeneration of damaged cells and tissues. In this review, we summarize recent advances in stem cell research focusing on the use of MSCs in the prevention and treatment of newborn BPD, IVH and HIE, with particular emphasis on preclinical and clinical data.",

keywords = "clinical trial, infant, newborn, stem cell transplantation, stem cells",

author = "Ahn, \{So Yoon\} and Park, \{Won Soon\} and Sung, \{Se In\} and Chang, \{Yun Sil\}",

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year = "2021",

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doi = "10.1016/j.pedneo.2020.11.007",

language = "English",

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TY - JOUR

T1 - Mesenchymal stem cell therapy for intractable neonatal disorders

AU - Ahn, So Yoon

AU - Park, Won Soon

AU - Sung, Se In

AU - Chang, Yun Sil

PY - 2021/2

Y1 - 2021/2

N2 - Mesenchymal stem cell (MSC) transplantation has emerged as a new promising therapeutic strategy for the treatment of intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and hypoxic-ischemic encephalopathy (HIE). In response to inflammatory and noxious environments, MSCs secrete various paracrine factors that perform several reparative functions, including exerting anti-inflammatory, anti-oxidative, anti-apoptotic, and anti-fibrotic effects, to enhance the regeneration of damaged cells and tissues. In this review, we summarize recent advances in stem cell research focusing on the use of MSCs in the prevention and treatment of newborn BPD, IVH and HIE, with particular emphasis on preclinical and clinical data.

AB - Mesenchymal stem cell (MSC) transplantation has emerged as a new promising therapeutic strategy for the treatment of intractable and devastating neonatal disorders with complex multifactorial etiologies, including bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and hypoxic-ischemic encephalopathy (HIE). In response to inflammatory and noxious environments, MSCs secrete various paracrine factors that perform several reparative functions, including exerting anti-inflammatory, anti-oxidative, anti-apoptotic, and anti-fibrotic effects, to enhance the regeneration of damaged cells and tissues. In this review, we summarize recent advances in stem cell research focusing on the use of MSCs in the prevention and treatment of newborn BPD, IVH and HIE, with particular emphasis on preclinical and clinical data.

KW - clinical trial

KW - infant, newborn

KW - stem cell transplantation

KW - stem cells

UR - https://www.scopus.com/pages/publications/85099664962

U2 - 10.1016/j.pedneo.2020.11.007

DO - 10.1016/j.pedneo.2020.11.007

M3 - Review article

C2 - 33485822

AN - SCOPUS:85099664962

SN - 1875-9572

VL - 62

SP - S16-S21

JO - Pediatrics and Neonatology

JF - Pediatrics and Neonatology

ER -

Mesenchymal stem cell therapy for intractable neonatal disorders

Abstract

Keywords

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