Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis

Sungran Huh; Young Soo Kim; Eunsun Jung; Jihee Lim; Kwang Sun Jung; Myeong Ok Kim; Jongsung Lee; Deokhoon Park

doi:10.1248/bpb.33.1242

Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis

Sungran Huh, Young Soo Kim, Eunsun Jung, Jihee Lim, Kwang Sun Jung, Myeong Ok Kim, Jongsung Lee, Deokhoon Park

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.

Original language	English
Pages (from-to)	1242-1245
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	33
Issue number	7
DOIs	https://doi.org/10.1248/bpb.33.1242
State	Published - 2010
Externally published	Yes

Keywords

Fatty acid alkyl ester
Melanogenesis
Oxalis triangularis

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10.1248/bpb.33.1242

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title = "Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis",

abstract = "Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.",

keywords = "Fatty acid alkyl ester, Melanogenesis, Oxalis triangularis",

author = "Sungran Huh and Kim, \{Young Soo\} and Eunsun Jung and Jihee Lim and Jung, \{Kwang Sun\} and Kim, \{Myeong Ok\} and Jongsung Lee and Deokhoon Park",

year = "2010",

doi = "10.1248/bpb.33.1242",

language = "English",

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pages = "1242--1245",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

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TY - JOUR

T1 - Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis

AU - Huh, Sungran

AU - Kim, Young Soo

AU - Jung, Eunsun

AU - Lim, Jihee

AU - Jung, Kwang Sun

AU - Kim, Myeong Ok

AU - Lee, Jongsung

AU - Park, Deokhoon

PY - 2010

Y1 - 2010

N2 - Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.

AB - Ten fatty acid alkyl esters isolated from Oxalis triangularis, were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.

KW - Fatty acid alkyl ester

KW - Melanogenesis

KW - Oxalis triangularis

UR - https://www.scopus.com/pages/publications/77954498566

U2 - 10.1248/bpb.33.1242

DO - 10.1248/bpb.33.1242

M3 - Article

C2 - 20606321

AN - SCOPUS:77954498566

SN - 0918-6158

VL - 33

SP - 1242

EP - 1245

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 7

ER -

Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis

Abstract

Keywords

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