MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease

Wook Joo Kwon; Young Hwan Hwang; Hyeon Kim Jae; Kook Hwan Oh; Hyunho Kim; Doo Shin Hyoung; Woo Kyung Chung; Jaeseok Yang; Soo Park Kyong; Curie Ahn

doi:10.3346/jkms.2007.22.4.611

MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease

Wook Joo Kwon, Young Hwan Hwang, Hyeon Kim Jae, Kook Hwan Oh, Hyunho Kim, Doo Shin Hyoung, Woo Kyung Chung, Jaeseok Yang, Soo Park Kyong, Curie Ahn

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Macrophage infiltration has been observed in the renal biopsy specimens of diabetic nephropathy (DN), and hyperglycemic state stimulates the renal expression of RANTES (regulated upon activation, normal T-cell expressed and secreted) and MCP-1 (monocyte chemoattractant protein-1). Upregulation of RANTES and MCP-1 with infiltrating macrophages may play a crucial role in the development and progression of DN. Genetic polymorphisms of RANTES and its receptors were reported to be independent risk factors for DN. We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM. There were no differences in the frequencies of SNPs and the distribution of haplotypes of RANTES promoter SNPs between two groups. In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN.

Original language	English
Pages (from-to)	611-615
Number of pages	5
Journal	Journal of Korean Medical Science
Volume	22
Issue number	4
DOIs	https://doi.org/10.3346/jkms.2007.22.4.611
State	Published - Aug 2007
Externally published	Yes

Keywords

Diabetes mellitus, type 2
Diabetic nephropathies
Kidney failure, chronic
Monocyte chemoattractant proteins
Polymorphism, single nucleotide polymorphisms
RANTES

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3346/jkms.2007.22.4.611

Cite this

@article{82a53b311ff64cdba6837d6f70e49079,

title = "MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease",

abstract = "Macrophage infiltration has been observed in the renal biopsy specimens of diabetic nephropathy (DN), and hyperglycemic state stimulates the renal expression of RANTES (regulated upon activation, normal T-cell expressed and secreted) and MCP-1 (monocyte chemoattractant protein-1). Upregulation of RANTES and MCP-1 with infiltrating macrophages may play a crucial role in the development and progression of DN. Genetic polymorphisms of RANTES and its receptors were reported to be independent risk factors for DN. We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM. There were no differences in the frequencies of SNPs and the distribution of haplotypes of RANTES promoter SNPs between two groups. In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN.",

keywords = "Diabetes mellitus, type 2, Diabetic nephropathies, Kidney failure, chronic, Monocyte chemoattractant proteins, Polymorphism, single nucleotide polymorphisms, RANTES",

author = "Kwon, \{Wook Joo\} and Hwang, \{Young Hwan\} and Jae, \{Hyeon Kim\} and Oh, \{Kook Hwan\} and Hyunho Kim and Hyoung, \{Doo Shin\} and Chung, \{Woo Kyung\} and Jaeseok Yang and Kyong, \{Soo Park\} and Curie Ahn",

year = "2007",

month = aug,

doi = "10.3346/jkms.2007.22.4.611",

language = "English",

volume = "22",

pages = "611--615",

journal = "Journal of Korean Medical Science",

issn = "1011-8934",

publisher = "Korean Academy of Medical Science",

number = "4",

}

TY - JOUR

T1 - MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease

AU - Kwon, Wook Joo

AU - Hwang, Young Hwan

AU - Jae, Hyeon Kim

AU - Oh, Kook Hwan

AU - Kim, Hyunho

AU - Hyoung, Doo Shin

AU - Chung, Woo Kyung

AU - Yang, Jaeseok

AU - Kyong, Soo Park

AU - Ahn, Curie

PY - 2007/8

Y1 - 2007/8

N2 - Macrophage infiltration has been observed in the renal biopsy specimens of diabetic nephropathy (DN), and hyperglycemic state stimulates the renal expression of RANTES (regulated upon activation, normal T-cell expressed and secreted) and MCP-1 (monocyte chemoattractant protein-1). Upregulation of RANTES and MCP-1 with infiltrating macrophages may play a crucial role in the development and progression of DN. Genetic polymorphisms of RANTES and its receptors were reported to be independent risk factors for DN. We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM. There were no differences in the frequencies of SNPs and the distribution of haplotypes of RANTES promoter SNPs between two groups. In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN.

AB - Macrophage infiltration has been observed in the renal biopsy specimens of diabetic nephropathy (DN), and hyperglycemic state stimulates the renal expression of RANTES (regulated upon activation, normal T-cell expressed and secreted) and MCP-1 (monocyte chemoattractant protein-1). Upregulation of RANTES and MCP-1 with infiltrating macrophages may play a crucial role in the development and progression of DN. Genetic polymorphisms of RANTES and its receptors were reported to be independent risk factors for DN. We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM. There were no differences in the frequencies of SNPs and the distribution of haplotypes of RANTES promoter SNPs between two groups. In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN.

KW - Diabetes mellitus, type 2

KW - Diabetic nephropathies

KW - Kidney failure, chronic

KW - Monocyte chemoattractant proteins

KW - Polymorphism, single nucleotide polymorphisms

KW - RANTES

UR - https://www.scopus.com/pages/publications/34548591177

U2 - 10.3346/jkms.2007.22.4.611

DO - 10.3346/jkms.2007.22.4.611

M3 - Article

C2 - 17728497

AN - SCOPUS:34548591177

SN - 1011-8934

VL - 22

SP - 611

EP - 615

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 4

ER -

MCP-1 and RANTES polymorphisms in Korean diabetic end-stage renal disease

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this