Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

Christine Beemelmanns; Timothy R. Ramadhar; Ki Hyun Kim; Jonathan L. Klassen; Shugeng Cao; Thomas P. Wyche; Yanpeng Hou; Michael Poulsen; Tim S. Bugni; Cameron R. Currie; Jon Clardy

doi:10.1021/acs.orglett.6b03831

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

Christine Beemelmanns
, Timothy R. Ramadhar
, Ki Hyun Kim
, Jonathan L. Klassen
, Shugeng Cao
, Thomas P. Wyche
, Yanpeng Hou
, Michael Poulsen
, Tim S. Bugni
, Cameron R. Currie
, Jon Clardy

Department of Pharmacy

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
Harvard University
University of Connecticut
University of Hawai'i at Hilo
University of Wisconsin-Madison
University of Copenhagen

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39’s sequenced genome revealed the macrotermycin’s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	5
DOIs	https://doi.org/10.1021/acs.orglett.6b03831
State	Published - 3 Mar 2017

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title = "Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39",

abstract = "Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39{\textquoteright}s sequenced genome revealed the macrotermycin{\textquoteright}s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.",

author = "Christine Beemelmanns and Ramadhar, \{Timothy R.\} and Kim, \{Ki Hyun\} and Klassen, \{Jonathan L.\} and Shugeng Cao and Wyche, \{Thomas P.\} and Yanpeng Hou and Michael Poulsen and Bugni, \{Tim S.\} and Currie, \{Cameron R.\} and Jon Clardy",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

month = mar,

day = "3",

doi = "10.1021/acs.orglett.6b03831",

language = "English",

volume = "19",

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journal = "Organic Letters",

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T1 - Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

AU - Beemelmanns, Christine

AU - Ramadhar, Timothy R.

AU - Kim, Ki Hyun

AU - Klassen, Jonathan L.

AU - Cao, Shugeng

AU - Wyche, Thomas P.

AU - Hou, Yanpeng

AU - Poulsen, Michael

AU - Bugni, Tim S.

AU - Currie, Cameron R.

AU - Clardy, Jon

PY - 2017/3/3

Y1 - 2017/3/3

N2 - Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39’s sequenced genome revealed the macrotermycin’s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

AB - Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39’s sequenced genome revealed the macrotermycin’s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

UR - https://www.scopus.com/pages/publications/85014644235

U2 - 10.1021/acs.orglett.6b03831

DO - 10.1021/acs.orglett.6b03831

M3 - Article

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AN - SCOPUS:85014644235

SN - 1523-7060

VL - 19

SP - 1000

EP - 1003

JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

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