Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

Christine Beemelmanns; Timothy R. Ramadhar; Ki Hyun Kim; Jonathan L. Klassen; Shugeng Cao; Thomas P. Wyche; Yanpeng Hou; Michael Poulsen; Tim S. Bugni; Cameron R. Currie; Jon Clardy

doi:10.1021/acs.orglett.6b03831

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

Christine Beemelmanns, Timothy R. Ramadhar, Ki Hyun Kim, Jonathan L. Klassen, Shugeng Cao, Thomas P. Wyche, Yanpeng Hou, Michael Poulsen, Tim S. Bugni, Cameron R. Currie, Jon Clardy

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39’s sequenced genome revealed the macrotermycin’s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

Original language	English
Pages (from-to)	1000-1003
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	5
DOIs	https://doi.org/10.1021/acs.orglett.6b03831
State	Published - 3 Mar 2017

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title = "Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39",

abstract = "Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39{\textquoteright}s sequenced genome revealed the macrotermycin{\textquoteright}s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.",

author = "Christine Beemelmanns and Ramadhar, \{Timothy R.\} and Kim, \{Ki Hyun\} and Klassen, \{Jonathan L.\} and Shugeng Cao and Wyche, \{Thomas P.\} and Yanpeng Hou and Michael Poulsen and Bugni, \{Tim S.\} and Currie, \{Cameron R.\} and Jon Clardy",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

month = mar,

day = "3",

doi = "10.1021/acs.orglett.6b03831",

language = "English",

volume = "19",

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journal = "Organic Letters",

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T1 - Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

AU - Beemelmanns, Christine

AU - Ramadhar, Timothy R.

AU - Kim, Ki Hyun

AU - Klassen, Jonathan L.

AU - Cao, Shugeng

AU - Wyche, Thomas P.

AU - Hou, Yanpeng

AU - Poulsen, Michael

AU - Bugni, Tim S.

AU - Currie, Cameron R.

AU - Clardy, Jon

PY - 2017/3/3

Y1 - 2017/3/3

N2 - Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39’s sequenced genome revealed the macrotermycin’s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

AB - Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39’s sequenced genome revealed the macrotermycin’s putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus and, of greater ecological relevance, they also had selective antifungal activity against a fungal parasite of the termite fungal garden.

UR - https://www.scopus.com/pages/publications/85014644235

U2 - 10.1021/acs.orglett.6b03831

DO - 10.1021/acs.orglett.6b03831

M3 - Article

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AN - SCOPUS:85014644235

SN - 1523-7060

VL - 19

SP - 1000

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JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39

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