Abstract
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
| Original language | English |
|---|---|
| Pages (from-to) | 584-591 |
| Number of pages | 8 |
| Journal | Experimental and Molecular Medicine |
| Volume | 41 |
| Issue number | 8 |
| DOIs | |
| State | Published - 31 Aug 2009 |
| Externally published | Yes |
Keywords
- Cell migration inhibition
- Chemotaxis
- Formyl peptide
- Interleukin-1β
- Leukocyte
- Lysophosphatidylglycerol
- Phagocytes
- Receptors
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