Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

Woong Shim Jae; Ho Jo Seong; Doo Kim Sang; Young Lee Ha; Jeanho Yun; Yoe Sik Bae

doi:10.3858/emm.2009.41.8.064

Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

Woong Shim Jae, Ho Jo Seong, Doo Kim Sang, Young Lee Ha, Jeanho Yun, Yoe Sik Bae

Dong-A University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.

Original language	English
Pages (from-to)	584-591
Number of pages	8
Journal	Experimental and Molecular Medicine
Volume	41
Issue number	8
DOIs	https://doi.org/10.3858/emm.2009.41.8.064
State	Published - 31 Aug 2009
Externally published	Yes

Keywords

Cell migration inhibition
Chemotaxis
Formyl peptide
Interleukin-1β
Leukocyte
Lysophosphatidylglycerol
Phagocytes
Receptors

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10.3858/emm.2009.41.8.064

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title = "Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes",

abstract = "In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.",

keywords = "Cell migration inhibition, Chemotaxis, Formyl peptide, Interleukin-1β, Leukocyte, Lysophosphatidylglycerol, Phagocytes, Receptors",

author = "Jae, \{Woong Shim\} and Seong, \{Ho Jo\} and Sang, \{Doo Kim\} and Ha, \{Young Lee\} and Jeanho Yun and Bae, \{Yoe Sik\}",

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doi = "10.3858/emm.2009.41.8.064",

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T1 - Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

AU - Jae, Woong Shim

AU - Seong, Ho Jo

AU - Sang, Doo Kim

AU - Ha, Young Lee

AU - Yun, Jeanho

AU - Bae, Yoe Sik

PY - 2009/8/31

Y1 - 2009/8/31

N2 - In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.

AB - In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.

KW - Cell migration inhibition

KW - Chemotaxis

KW - Formyl peptide

KW - Interleukin-1β

KW - Leukocyte

KW - Lysophosphatidylglycerol

KW - Phagocytes

KW - Receptors

UR - https://www.scopus.com/pages/publications/70249124541

U2 - 10.3858/emm.2009.41.8.064

DO - 10.3858/emm.2009.41.8.064

M3 - Article

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AN - SCOPUS:70249124541

SN - 1226-3613

VL - 41

SP - 584

EP - 591

JO - Experimental and Molecular Medicine

JF - Experimental and Molecular Medicine

IS - 8

ER -

Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

Abstract

Keywords

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