Loss of heterozygosity on the short arm of chromosome 17 in uterine cervical carcinomas

Sang Yoon Park; Young Soon Kang; Byoung Gie Kim; Seung Hoon Lee; Eui Don Lee; Kyung Hee Lee; Kee Bock Park; Je Ho Lee

doi:10.1016/0165-4608(94)00103-I

Loss of heterozygosity on the short arm of chromosome 17 in uterine cervical carcinomas

Sang Yoon Park, Young Soon Kang, Byoung Gie Kim, Seung Hoon Lee, Eui Don Lee, Kyung Hee Lee, Kee Bock Park, Je Ho Lee

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

DNA samples from 26 cervical carcinoma and normal tissue pairs were studied by restriction fragment length polymorphism (RFLP) analysis to determine the frequency of loss of heterozygosity (LOH) on 17p. Allelic loss in the p13.1 region of chromosome 17, known to contain the TP53 locus, was not detected in any of 10 informative cases. Instead, LOH was detected on 17p13.3 in eight (40%) of 20 informative cases with at least one of two 17p13.3 markers. Examination of the intragenic region of p53 in the same samples using polymerase chain reaction (PCR)-RFLP analysis showed no LOH in the gene (none of 16 informative individuals).

Original language	English
Pages (from-to)	74-78
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(94)00103-I
State	Published - Jan 1995
Externally published	Yes

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@article{9b7333b3bf1848b5bd17c9bce14a756a,

title = "Loss of heterozygosity on the short arm of chromosome 17 in uterine cervical carcinomas",

abstract = "DNA samples from 26 cervical carcinoma and normal tissue pairs were studied by restriction fragment length polymorphism (RFLP) analysis to determine the frequency of loss of heterozygosity (LOH) on 17p. Allelic loss in the p13.1 region of chromosome 17, known to contain the TP53 locus, was not detected in any of 10 informative cases. Instead, LOH was detected on 17p13.3 in eight (40\%) of 20 informative cases with at least one of two 17p13.3 markers. Examination of the intragenic region of p53 in the same samples using polymerase chain reaction (PCR)-RFLP analysis showed no LOH in the gene (none of 16 informative individuals).",

author = "Park, \{Sang Yoon\} and Kang, \{Young Soon\} and Kim, \{Byoung Gie\} and Lee, \{Seung Hoon\} and Lee, \{Eui Don\} and Lee, \{Kyung Hee\} and Park, \{Kee Bock\} and Lee, \{Je Ho\}",

year = "1995",

month = jan,

doi = "10.1016/0165-4608(94)00103-I",

language = "English",

volume = "79",

pages = "74--78",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

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TY - JOUR

T1 - Loss of heterozygosity on the short arm of chromosome 17 in uterine cervical carcinomas

AU - Park, Sang Yoon

AU - Kang, Young Soon

AU - Kim, Byoung Gie

AU - Lee, Seung Hoon

AU - Lee, Eui Don

AU - Lee, Kyung Hee

AU - Park, Kee Bock

AU - Lee, Je Ho

PY - 1995/1

Y1 - 1995/1

N2 - DNA samples from 26 cervical carcinoma and normal tissue pairs were studied by restriction fragment length polymorphism (RFLP) analysis to determine the frequency of loss of heterozygosity (LOH) on 17p. Allelic loss in the p13.1 region of chromosome 17, known to contain the TP53 locus, was not detected in any of 10 informative cases. Instead, LOH was detected on 17p13.3 in eight (40%) of 20 informative cases with at least one of two 17p13.3 markers. Examination of the intragenic region of p53 in the same samples using polymerase chain reaction (PCR)-RFLP analysis showed no LOH in the gene (none of 16 informative individuals).

AB - DNA samples from 26 cervical carcinoma and normal tissue pairs were studied by restriction fragment length polymorphism (RFLP) analysis to determine the frequency of loss of heterozygosity (LOH) on 17p. Allelic loss in the p13.1 region of chromosome 17, known to contain the TP53 locus, was not detected in any of 10 informative cases. Instead, LOH was detected on 17p13.3 in eight (40%) of 20 informative cases with at least one of two 17p13.3 markers. Examination of the intragenic region of p53 in the same samples using polymerase chain reaction (PCR)-RFLP analysis showed no LOH in the gene (none of 16 informative individuals).

UR - https://www.scopus.com/pages/publications/0028881533

U2 - 10.1016/0165-4608(94)00103-I

DO - 10.1016/0165-4608(94)00103-I

M3 - Article

C2 - 7850756

AN - SCOPUS:0028881533

SN - 0165-4608

VL - 79

SP - 74

EP - 78

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Loss of heterozygosity on the short arm of chromosome 17 in uterine cervical carcinomas

Abstract

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