TY - JOUR
T1 - Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression
AU - Lee, Ga In
AU - Son, Ki Young
AU - Park, Kyung Ah
AU - Kong, Doo Sik
AU - Oh, Sei Yeul
N1 - Publisher Copyright:
© 2020 American Academy of Neurology.
PY - 2021/1/5
Y1 - 2021/1/5
N2 - Objective: To test the hypothesis that there was a temporal change in the retinal microstructure after decompression surgery for chiasmal compression, the 1-year longitudinal changes in the inner and outer retinal thickness after decompression surgery were analyzed using spectral-domain optical coherence tomography (SD-OCT) with linear mixed-effects models. Methods: SD-OCT was obtained from 87 eyes with chiasmal compression and compared to 100 healthy controls. The preoperative and 1-year postoperative longitudinal changes in the retinal layer thickness were measured. The thickness of each of the following retinal layers was analyzed: the macular retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), the inner plexiform layer (IPL), the inner nuclear layer, the outer plexiform layer, the outer nuclear layer, and the photoreceptor layer. Results: The RNFL, GCL, and IPL showed thinning at a rate of 1.068 m/y (95% confidence interval [CI], 0.523, 1.613), 1.189 m/y (95% CI 0.452, 1.925), and 1.177 m/y (95% CI 0.645, 1.709), respectively, after decompression surgery. The preoperative thickness of the intraretinal layer was associated with postoperative visual field recovery (RNFL, odds ratio [OR] 1.221, 95% CI 1.058, 1.410; GCL, OR 1.133, 95% CI 1.024, 1.254; and IPL, OR 1.174, 95% CI 1.002, 1.376). Conclusion: sThe changes in retinal microstructure persisted and progressed in eyes with chiasmal compression after decompression surgery. The findings provide insight into the biological and anatomical sequelae following chiasmal compression. The preoperative thickness of the inner retinal layers was associated with postoperative visual field recovery.
AB - Objective: To test the hypothesis that there was a temporal change in the retinal microstructure after decompression surgery for chiasmal compression, the 1-year longitudinal changes in the inner and outer retinal thickness after decompression surgery were analyzed using spectral-domain optical coherence tomography (SD-OCT) with linear mixed-effects models. Methods: SD-OCT was obtained from 87 eyes with chiasmal compression and compared to 100 healthy controls. The preoperative and 1-year postoperative longitudinal changes in the retinal layer thickness were measured. The thickness of each of the following retinal layers was analyzed: the macular retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), the inner plexiform layer (IPL), the inner nuclear layer, the outer plexiform layer, the outer nuclear layer, and the photoreceptor layer. Results: The RNFL, GCL, and IPL showed thinning at a rate of 1.068 m/y (95% confidence interval [CI], 0.523, 1.613), 1.189 m/y (95% CI 0.452, 1.925), and 1.177 m/y (95% CI 0.645, 1.709), respectively, after decompression surgery. The preoperative thickness of the intraretinal layer was associated with postoperative visual field recovery (RNFL, odds ratio [OR] 1.221, 95% CI 1.058, 1.410; GCL, OR 1.133, 95% CI 1.024, 1.254; and IPL, OR 1.174, 95% CI 1.002, 1.376). Conclusion: sThe changes in retinal microstructure persisted and progressed in eyes with chiasmal compression after decompression surgery. The findings provide insight into the biological and anatomical sequelae following chiasmal compression. The preoperative thickness of the inner retinal layers was associated with postoperative visual field recovery.
UR - https://www.scopus.com/pages/publications/85099172603
U2 - 10.1212/WNL.0000000000011087
DO - 10.1212/WNL.0000000000011087
M3 - Article
C2 - 33093228
AN - SCOPUS:85099172603
SN - 0028-3878
VL - 96
SP - E131-E140
JO - Neurology
JF - Neurology
IS - 1
ER -