Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation

Hyungwoo Lee; Jun Seung Mun; Jin San Lee; Yeongu Chung; Woo Ram Jung; Joon Seong Kang; Sung Min Park; Wonok Kang; Se Hyeon Kim; Dae Won Seo; Duk L. Na; Young Min Shon; Sang Joon Kim

doi:10.1109/EMBC44109.2020.9176408

Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation

Hyungwoo Lee, Jun Seung Mun, Jin San Lee, Yeongu Chung, Woo Ram Jung, Joon Seong Kang, Sung Min Park, Wonok Kang, Se Hyeon Kim, Dae Won Seo, Duk L. Na, Young Min Shon, Sang Joon Kim

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Long-term preclinical study available extracranial brain activator (ECBA) system, ECBAv2, is proposed for the non-anesthetic canine models. The titanium-packaged module shows enhanced durability, even after a year of implantation in the scalp. In addition, the wearable helmet type base station provides a stable experimental environment without anesthesia. In this work, HFS stimulation is induced to six canine models for 30 minutes every day over 4 weeks (10Hz, 40Hz and no stimulation for each pair of subjects). Pre- and post-HFS stimulation PET-CT image shows remarkable increases of glucose metabolism in the temporal and parietal lobes. Moreover, both the 40-Hz and 10-Hz groups shows noticeable increase and the former group has more increments than the latter. Our results establish that HFS stimulation definitely worked as facilitating brain activity which may affect memory and sensory skills, respectively.

Original language	English
Title of host publication	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Enabling Innovative Technologies for Global Healthcare, EMBC 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5184-5187
Number of pages	4
ISBN (Electronic)	9781728119908
DOIs	https://doi.org/10.1109/EMBC44109.2020.9176408
State	Published - Jul 2020
Externally published	Yes
Event	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada Duration: 20 Jul 2020 → 24 Jul 2020

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2020-July
ISSN (Print)	1557-170X

Conference

Conference	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
Country/Territory	Canada
City	Montreal
Period	20/07/20 → 24/07/20

Access to Document

10.1109/EMBC44109.2020.9176408

Cite this

Lee, H., Mun, J. S., San Lee, J., Chung, Y., Jung, W. R., Seong Kang, J., Park, S. M., Kang, W., Kim, S. H., Won Seo, D., Na, D. L., Shon, Y. M., & Kim, S. J. (2020). Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020 (pp. 5184-5187). Article 9176408 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC44109.2020.9176408

Lee, Hyungwoo ; Mun, Jun Seung ; San Lee, Jin et al. / Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation. 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 5184-5187 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{722b7929649248ada94bf58fb4e97aef,

title = "Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation",

abstract = "Long-term preclinical study available extracranial brain activator (ECBA) system, ECBAv2, is proposed for the non-anesthetic canine models. The titanium-packaged module shows enhanced durability, even after a year of implantation in the scalp. In addition, the wearable helmet type base station provides a stable experimental environment without anesthesia. In this work, HFS stimulation is induced to six canine models for 30 minutes every day over 4 weeks (10Hz, 40Hz and no stimulation for each pair of subjects). Pre- and post-HFS stimulation PET-CT image shows remarkable increases of glucose metabolism in the temporal and parietal lobes. Moreover, both the 40-Hz and 10-Hz groups shows noticeable increase and the former group has more increments than the latter. Our results establish that HFS stimulation definitely worked as facilitating brain activity which may affect memory and sensory skills, respectively.",

author = "Hyungwoo Lee and Mun, \{Jun Seung\} and \{San Lee\}, Jin and Yeongu Chung and Jung, \{Woo Ram\} and \{Seong Kang\}, Joon and Park, \{Sung Min\} and Wonok Kang and Kim, \{Se Hyeon\} and \{Won Seo\}, Dae and Na, \{Duk L.\} and Shon, \{Young Min\} and Kim, \{Sang Joon\}",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE.; 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 ; Conference date: 20-07-2020 Through 24-07-2020",

year = "2020",

month = jul,

doi = "10.1109/EMBC44109.2020.9176408",

language = "English",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "5184--5187",

booktitle = "42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society",

}

Lee, H, Mun, JS, San Lee, J, Chung, Y, Jung, WR, Seong Kang, J, Park, SM, Kang, W, Kim, SH, Won Seo, D, Na, DL, Shon, YM & Kim, SJ 2020, Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation. in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020., 9176408, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2020-July, Institute of Electrical and Electronics Engineers Inc., pp. 5184-5187, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020, Montreal, Canada, 20/07/20. https://doi.org/10.1109/EMBC44109.2020.9176408

Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation. / Lee, Hyungwoo; Mun, Jun Seung; San Lee, Jin et al.
42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 5184-5187 9176408 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation

AU - Lee, Hyungwoo

AU - Mun, Jun Seung

AU - San Lee, Jin

AU - Chung, Yeongu

AU - Jung, Woo Ram

AU - Seong Kang, Joon

AU - Park, Sung Min

AU - Kang, Wonok

AU - Kim, Se Hyeon

AU - Won Seo, Dae

AU - Na, Duk L.

AU - Shon, Young Min

AU - Kim, Sang Joon

PY - 2020/7

Y1 - 2020/7

N2 - Long-term preclinical study available extracranial brain activator (ECBA) system, ECBAv2, is proposed for the non-anesthetic canine models. The titanium-packaged module shows enhanced durability, even after a year of implantation in the scalp. In addition, the wearable helmet type base station provides a stable experimental environment without anesthesia. In this work, HFS stimulation is induced to six canine models for 30 minutes every day over 4 weeks (10Hz, 40Hz and no stimulation for each pair of subjects). Pre- and post-HFS stimulation PET-CT image shows remarkable increases of glucose metabolism in the temporal and parietal lobes. Moreover, both the 40-Hz and 10-Hz groups shows noticeable increase and the former group has more increments than the latter. Our results establish that HFS stimulation definitely worked as facilitating brain activity which may affect memory and sensory skills, respectively.

AB - Long-term preclinical study available extracranial brain activator (ECBA) system, ECBAv2, is proposed for the non-anesthetic canine models. The titanium-packaged module shows enhanced durability, even after a year of implantation in the scalp. In addition, the wearable helmet type base station provides a stable experimental environment without anesthesia. In this work, HFS stimulation is induced to six canine models for 30 minutes every day over 4 weeks (10Hz, 40Hz and no stimulation for each pair of subjects). Pre- and post-HFS stimulation PET-CT image shows remarkable increases of glucose metabolism in the temporal and parietal lobes. Moreover, both the 40-Hz and 10-Hz groups shows noticeable increase and the former group has more increments than the latter. Our results establish that HFS stimulation definitely worked as facilitating brain activity which may affect memory and sensory skills, respectively.

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M3 - Conference contribution

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SP - 5184

EP - 5187

BT - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020

Y2 - 20 July 2020 through 24 July 2020

ER -

Lee H, Mun JS, San Lee J, Chung Y, Jung WR, Seong Kang J et al. Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 5184-5187. 9176408. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC44109.2020.9176408

Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation

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