TY - JOUR
T1 - Lignans from the Twigs of Euonymus alatus (Thunb.) Siebold and Their Biological Evaluation
AU - Lee, Seulah
AU - Moon, Eunjung
AU - Choi, Sang Un
AU - Kim, Ki Hyun
N1 - Publisher Copyright:
© 2016 Wiley-VHCA AG, Zürich
PY - 2016/10/1
Y1 - 2016/10/1
N2 - A new sesquilignan, euonymolin A (1), and six known lignans, (−)-de-O-methylmagnolin (2), (+)-de-O-methylepimagnolin A (3), (+)-syringaresinol (4), (+)-pinoresinol (5), (+)-medioresinol (6), and (+)-lariciresinol 4′-O-β-d-glucopyranoside (7), were isolated from the twigs of Euonymus alatus (Thunb.) Siebold (Celastraceae). The structures of the isolated compounds were elucidated based on spectroscopic analyses, including extensive 1D- and 2D-NMR techniques, HR-MS analysis and circular dichroism (CD) data, and the literature data. All of the isolated compounds were evaluated for antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines and inhibition of nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated BV2 cell line. All compounds showed cytotoxicity against the SK-MEL-2 cell line with IC50 values of 23.24 – 48.14 μm and inhibited NO production in LPS-activated BV-2 cells with IC50 values of 6.75 – 23.53 μm.
AB - A new sesquilignan, euonymolin A (1), and six known lignans, (−)-de-O-methylmagnolin (2), (+)-de-O-methylepimagnolin A (3), (+)-syringaresinol (4), (+)-pinoresinol (5), (+)-medioresinol (6), and (+)-lariciresinol 4′-O-β-d-glucopyranoside (7), were isolated from the twigs of Euonymus alatus (Thunb.) Siebold (Celastraceae). The structures of the isolated compounds were elucidated based on spectroscopic analyses, including extensive 1D- and 2D-NMR techniques, HR-MS analysis and circular dichroism (CD) data, and the literature data. All of the isolated compounds were evaluated for antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines and inhibition of nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated BV2 cell line. All compounds showed cytotoxicity against the SK-MEL-2 cell line with IC50 values of 23.24 – 48.14 μm and inhibited NO production in LPS-activated BV-2 cells with IC50 values of 6.75 – 23.53 μm.
KW - Cytotoxicity
KW - Euonymolin A
KW - Euonymus alatus
KW - Lignans
KW - Nitric oxide
UR - https://www.scopus.com/pages/publications/84990216710
U2 - 10.1002/cbdv.201600083
DO - 10.1002/cbdv.201600083
M3 - Article
C2 - 27447684
AN - SCOPUS:84990216710
SN - 1612-1872
SP - 1391
EP - 1396
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
ER -