TY - JOUR
T1 - Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities
AU - Kim, Chung Sub
AU - Subedi, Lalita
AU - Kim, Sun Yeou
AU - Choi, Sang Un
AU - Kim, Ki Hyun
AU - Lee, Kang Ro
N1 - Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.
PY - 2015/5/22
Y1 - 2015/5/22
N2 - Phytochemical investigation of the twigs of Chaenomeles sinensis led to the isolation and identification of six new lignan glycosides, chaenomiside A-F (1-6), along with five known ones (7-11). Their chemical structures were determined by spectroscopic methods, including NMR, MS, ECD, and GC/MS analyses. All the isolated compounds (1-11) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-activated murine microglial cells and the secretion of nerve growth factor (NGF) in a C6 rat glioma cell line. Compound 6 significantly reduced NO levels in the murine microglia BV2 cells with an IC50 value of 21.3 μM, and compounds 1, 3, and 6 were potent stimulants of NGF release with stimulation levels of 151.74 ± 6.77%, 144.31 ± 7.49%, and 167.61 ± 18.5%, respectively.
AB - Phytochemical investigation of the twigs of Chaenomeles sinensis led to the isolation and identification of six new lignan glycosides, chaenomiside A-F (1-6), along with five known ones (7-11). Their chemical structures were determined by spectroscopic methods, including NMR, MS, ECD, and GC/MS analyses. All the isolated compounds (1-11) were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-activated murine microglial cells and the secretion of nerve growth factor (NGF) in a C6 rat glioma cell line. Compound 6 significantly reduced NO levels in the murine microglia BV2 cells with an IC50 value of 21.3 μM, and compounds 1, 3, and 6 were potent stimulants of NGF release with stimulation levels of 151.74 ± 6.77%, 144.31 ± 7.49%, and 167.61 ± 18.5%, respectively.
UR - https://www.scopus.com/pages/publications/84930208066
U2 - 10.1021/acs.jnatprod.5b00090
DO - 10.1021/acs.jnatprod.5b00090
M3 - Article
C2 - 25894905
AN - SCOPUS:84930208066
SN - 0163-3864
VL - 78
SP - 1174
EP - 1178
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -